AAV Thermostability Assessment with Micro-Flow Imaging

The spotlight demonstrates the use of the Micro Flow Imaging (MFI™) system in evaluating the thermal stability of AAV viral particles and its application in formulation development. Read on to find out how:

• Subvisible particles (1-100 µm) were evaluated for heat-stressed AAV9 samples at 37°C and 75°C
• The MFI system provides real-time visualization of different subvisible particles, offering several benefits compared to other USP-accepting methods such as light obscuration and membrane microscopy