BaseScope™ Probes for MAGEA Gene Family Detection

Ongoing clinical trials of cancer vaccines and adoptive cell therapies target members of the melanoma-associated antigen (MAGE) family, which are highly prevalent in tumors. However, their highly homologous nature, with >90% sequence identity between the MAGE-A genes, poses significant challenges to their specific detection in tumors. Due to antibody cross-reactivity there is limited capability of protein-specific assays to detect and distinguish between the various MAGE-A antigens. Here, the BaseScope™ RNA in situ hybridization (ISH) assay was developed to discern MAGEA1, MAGEA3, MAGEA4, and MAGEA10 expression in cell lines and tumor tissues.

Download this product listing to discover our range of probes for MAGEA detection.