A Chromogenic in situ Hybridization Assay For High-Resolution Detection of DNA Copy Number and Structural Variations

For accurate and reliable detection of DNA aberrations, current commercial FISH techniques fall short on morphological detail due to the use of fluorescent nuclear staining and reliance on expensive high-resolution microscopes to visualize gene rearrangement and copy number variation signals. Additionally, use of Bacterial Artificial Chromosome (BAC) clone-based probes that are large and tend to span multiple genes, lack single gene detection specificity limiting the scale and development of DNA research.

Discover the benefits of using our chromogenic DNA in situ hybridization (ISH) technology for your DNA research in this whitepaper. DNAscope™ employs the proven “double-Z” probe design and signal amplification system of RNAscope™, enabling rapid and flexible probe development for any DNA target enabling visualization of target in paraffin embedded tissues.