miRNAscope™: a novel in situ hybridization technology for the detection of small regulatory RNAs with spatial and morphological context

In this study, an RNA ISH assay was developed for the detection of small RNA species with unparalleled detection sensitivity and specificity, enabling morphological information with single cell resolution. The miRNAscope™ assay will improve the understanding of small RNA species in their native context and will elucidate their associated gene regulatory networks involved in health and disease.

The miRNAscope Assay is a robust RNA in situ hybridization assay enabling the detection of small RNAs in tissues with spatial and morphological context at single cell resolution. Key applications include: miRNAs, siRNA, ASO, and other short RNA sequences (17-50nt). The assay will be a single-plex chromogenic (Fast-RED) assay compatible with the Manual platform or the fully automated Leica platform.