RNAscope™ Albumin RNA ISH

Albumin, a protein synthesized by hepatocytes, was first proposed as a marker of hepatocellular differentiation in 1980s. However, detection of albumin using IHC proved challenging primarily due to its ubiquitous presence as a serum protein, leading to high background staining. The application of RNA ISH technology for the detection of albumin mRNA rather than protein successfully addressed this issue. In this regard, albumin mRNA has recently been identified as a marker of hepatocellular differentiation that is highly useful in the evaluation of hepatocellular neoplasms.