RNAscope Gene Therapy Brochure - Powered by RNAscope - Accelerate Gene Therapy Development

RNAscope™ in situ hybridization (ISH) is the most preferred and trusted technology by leading pharmaceutical and biotech companies for evaluation of therapeutic biodistribution and cellular tropism in pre-clinical model systems. Quantify changes in gene expression and cellular function confidently, to optimize therapeutic efficacy and safety.

• Visualize tissue biodistribution and cellular tropism of viral vectors such as AAV, transgene and RNA therapeutics delivered by non-viral platforms with single-molecule sensitivity and sub-cellular resolution.
• Select engineered vectors and capsids for highest transduction efficiency.
• Quantify expression and persistence of transgenes including codon-optimized or gene-edited cargo. 
• Evaluate therapeutic efficacy including RNA efficiency within targeted cells and tissues. 
• Improve safety by evaluating dosing and identifying off-target events in relevant organs.