Spatial RNA Profiling in the Nervous System with the RNAscope™ Technology

The nervous system is one of the most complex tissues composed of numerous cell types and subtypes organized with delicate topological characteristics, presenting unique challenges to traditional gene expression analysis techniques. Interrogation of the complex nervous system, especially the brain, requires a highly sensitive, specific, and multiplexed spatial approach with single-cell resolution.

RNAscope™ technology has become a key method for detecting gene expression within the nervous system. In this book, we highlight the use of the RNAscope technology in the neuroscience field with several examples from studies performed at ACD, as well as recent peer-reviewed publications showing how researchers have taken advantage of the RNAscope technology to complement their neuroscience research with spatial genomics.