Necroptosis Signaling Pathway

Necroptosis is a programmed form of necrotic cell death which has been considered a form of passive cell death through regulated cell signaling pathways. The concept of necroptosis came from the discovery that TNFa-mediated necrosis can be inhibited by a specific inhibitor of RIP1 kinase, necrostatin-1. Necroptosis has now been established as a regulated necrotic cell death pathway controlled by RIP1 and RIP3 kinases. Necroptosis plays a role in various pathological forms of cell death, including ischemic brain injury, neurodegenerative diseases and viral infections.

Find available products by clicking on key proteins in this interactive pathway below: