NFKB Signaling Pathway

Nuclear factor kappa beta (NFkB) is a nearly ubiquitous pathway responsible for mediating DNA transcription, and therefore cell function. The pathway is activated by a variety of stimuli including cellular stress, cytokines, free radicals, UV radiation, oxidized LDL, and bacterial/viral infection. Activated NFkB is translocated to the nucleus where it binds to specific sequences of DNA called response elements. This DNA/NFkB complex then recruits RNA polymerase and other coactivators, which transcribe downstream DNA into mRNA, for protein synthesis. Find available products by clicking on key proteins in the NFkB interactive pathway below.