Webinar: Exploiting Tumor Hypoxia for Targeted Immunotherapy

The tumor microenvironment is a complex system, and hypoxia plays a role in most solid tumors, contributing to immune suppression and immunotherapy resistance. Learn about the role of hypoxia in the anti-tumor T cell response and targeted immunotherapy from the experts, Greg Delgoffe, PhD, and James Arnold, PhD .

Learning Objectives:

• The role of hypoxia in mitochondrial dysfunction and T cell exhaustion
• Improving response to immune checkpoint blockade therapy by modulating the cellular response to hypoxia
• Engineering of a hypoxia-sensing chimeric antigen receptor (CAR) T cell
• Selective expression of CAR within tumor limits non-specific activation of CAR T cells targeting a ubiquitously expressed protein