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4-1BB/TNFRSF9/CD137 Products

4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell proliferation, activation, and/or survival and can enhance the activation-induced cell death of repetitively stimulated T cells. 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and activation of mast cells.

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385 results for "4-1BB/TNFRSF9/CD137" in Products

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385 results for "4-1BB/TNFRSF9/CD137" in Products

4-1BB/TNFRSF9/CD137 Products

4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell proliferation, activation, and/or survival and can enhance the activation-induced cell death of repetitively stimulated T cells. 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and activation of mast cells.

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Applications: WB, Simple Western, Flow, IHC, AgAct, CyTOF-ready, ICC
Reactivity: Human
Applications: WB, Flow, IHC, AgAct, CyTOF-ready
Reactivity: Mouse
Applications: AgAct
Reactivity: Mouse
Applications: WB, Flow, ICC
Reactivity: Human
Applications: WB, Simple Western, Flow, CyTOF-ready, ICC
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: WB, Flow
Reactivity: Mouse
Applications: WB, Flow, CyTOF-ready
Reactivity: Human
Applications: WB, Flow, CyTOF-ready
Reactivity: Mouse
Applications: Flow
Reactivity: Mouse
Applications: Flow, AgAct, CyTOF-ready
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: Flow, CyTOF-ready, ICC
Reactivity: Rat
Applications: Flow
Reactivity: Human
Applications: Flow
Reactivity: Mouse
Applications: Flow
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: Flow
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: Flow
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: Flow
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: Flow
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: Flow
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: Flow
Reactivity: Human

Recombinant Monoclonal Antibody.

Applications: Block
Reactivity: Mouse

Recombinant Monoclonal Antibody.

Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: WB, Block
Reactivity: Mouse
Applications: IHC, WB, ELISA, ICC/IF, Flow, B/N
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: Flow
Reactivity: Human
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