5-HT1D Receptor Antagonists: Small Molecules and Peptides
5-HT1D is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of 5-HT1D is mediated by G proteins that inhibit adenylate cyclase activity. There is an association between polymorphisms within the genes encoding 5-HT1D and 5-HT1B with anorexia nervosa (AN). mRNA concentrations of the 5-HT1D receptor and the transcription factors, NUDR and REST, were significantly increased in dorsal raphe nucleus-captured neurons of female major depressive disorder subjects.
2 results for "5-HT1D Receptor Antagonists Small Molecules and Peptides" in Products
2 results for "5-HT1D Receptor Antagonists Small Molecules and Peptides" in Products
5-HT1D Receptor Antagonists: Small Molecules and Peptides
5-HT1D is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of 5-HT1D is mediated by G proteins that inhibit adenylate cyclase activity. There is an association between polymorphisms within the genes encoding 5-HT1D and 5-HT1B with anorexia nervosa (AN). mRNA concentrations of the 5-HT1D receptor and the transcription factors, NUDR and REST, were significantly increased in dorsal raphe nucleus-captured neurons of female major depressive disorder subjects.
Selective 5-HT1D antagonist
| Chemical Name: | 1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective 5-HT1B and 5-HT1D antagonist
| Chemical Name: | N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
