5-HT4 Receptor Antagonists Products
5HT4R, also known as HTR4, is an approximately 45 kDa multipass serotonin receptor that is expressed in the brain, gastrointestinal tract, bladder, vascular endothelial cells, atrium, kidney, and adrenal gland. It is involved in the regulation of learning, memory, anxiety, smooth muscle contraction, and adrenal corticosteroid secretion. Alternate splicing of human 5HT4R generates multiple isoforms with either a 14 aa insertion in the second extracellular loop or a deletion or various substitutions in the C-terminal cytoplasmic region. Different isoforms show tissue specific expression patterns or increased activity in the absence of ligand. Human 5HT4R shares 94% and 88% aa sequence identity with mouse and rat 5HT4R, respectively.
4 results for "5-HT4 Receptor Antagonists" in Products
4 results for "5-HT4 Receptor Antagonists" in Products
5-HT4 Receptor Antagonists Products
5HT4R, also known as HTR4, is an approximately 45 kDa multipass serotonin receptor that is expressed in the brain, gastrointestinal tract, bladder, vascular endothelial cells, atrium, kidney, and adrenal gland. It is involved in the regulation of learning, memory, anxiety, smooth muscle contraction, and adrenal corticosteroid secretion. Alternate splicing of human 5HT4R generates multiple isoforms with either a 14 aa insertion in the second extracellular loop or a deletion or various substitutions in the C-terminal cytoplasmic region. Different isoforms show tissue specific expression patterns or increased activity in the absence of ligand. Human 5HT4R shares 94% and 88% aa sequence identity with mouse and rat 5HT4R, respectively.
Potent and selective 5-HT4 antagonist; active in vivo
| Chemical Name: | 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate |
| Purity: | ≥97% (HPLC) |
5-HT4 antagonist
| Chemical Name: | 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride |
Potent and selective 5-HT4 antagonist
| Chemical Name: | 1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester |
| Purity: | ≥98% (HPLC) |
5-HT4 antagonist
| Chemical Name: | 1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride |
| Purity: | ≥98% (HPLC) |
