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5'-Nucleotidase/CD73: Small Molecules and Peptides
CD73, an ecto-5-prime-nucleotidase, is a glycosyl phophatidylinositol-anchored ectoenzyme that forms a disulfide-linked homodimer. The 5-prime-nucleotidase activity of CD73 converts extracellular nucleoside 5-prime monophosphates to nucleosides. It is one of several enzymes responsible for the production of extracellular adenosine, a signaling molecule that is involved in responses to inflammation and tissue injury. Most cell types express CD73.
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