ABCA1 Products
ABCA1 (ATP-binding cassette, subfamily A member 1; also cholesterol efflux regulatory protein) is a 240-280 kDa member of the ABCA family, ABC transporter superfamily of molecules. Widely expressed, particularly by macrophages, ABCA1 participates in the transport of lipid across cell membranes. Once transported, ABCA1 is passed on to tethered ApoA-I to form HDL. Human ABCA1 is 2261 amino acids (aa) in length. It has up to 15 transmembrane segments with beginning and ending cytoplasmic domains and a large cytoplasmic central region. ABC transporters are found between aa 899-1311 and 1912-2144. Amino acids 2216-2221 are essential for lipid transport, and two intramolecular disulfide bonds are required for activity (Cys75-Cys309 and Cys1463/1465-Cys1477). There are three potential isoform variants of ABCA1. One possesses an alternative start site at Met61, while two others contain 12 aa and 123 aa substitutions for aa 241-2261, respectively. Over aa 1248-1350, human ABCA1 shares 97% aa identity with mouse ABCA1.
186 results for "ABCA1" in Products
186 results for "ABCA1" in Products
ABCA1 Products
ABCA1 (ATP-binding cassette, subfamily A member 1; also cholesterol efflux regulatory protein) is a 240-280 kDa member of the ABCA family, ABC transporter superfamily of molecules. Widely expressed, particularly by macrophages, ABCA1 participates in the transport of lipid across cell membranes. Once transported, ABCA1 is passed on to tethered ApoA-I to form HDL. Human ABCA1 is 2261 amino acids (aa) in length. It has up to 15 transmembrane segments with beginning and ending cytoplasmic domains and a large cytoplasmic central region. ABC transporters are found between aa 899-1311 and 1912-2144. Amino acids 2216-2221 are essential for lipid transport, and two intramolecular disulfide bonds are required for activity (Cys75-Cys309 and Cys1463/1465-Cys1477). There are three potential isoform variants of ABCA1. One possesses an alternative start site at Met61, while two others contain 12 aa and 123 aa substitutions for aa 241-2261, respectively. Over aa 1248-1350, human ABCA1 shares 97% aa identity with mouse ABCA1.
| Reactivity: | Human, Mouse, Rat, Canine, Primate, +9 More |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +9 More |
| Reactivity: | Human, Mouse, Rat, Rabbit |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #HJ1 |
| Applications: | IHC, WB, ICC/IF, Flow, CyTOF-ready |
![Western Blot: ABCA1 Antibody (HJ1)BSA Free [NB100-2068]](https://resources.bio-techne.com/images/products/ABCA1-Antibody-HJ1-Western-Blot-NB100-2068-img0012.jpg "Western Blot: ABCA1 Antibody (HJ1)BSA Free [NB100-2068]")
| Reactivity: | Mouse, Human (Negative) |
| Details: | Rat IgG1 kappa Monoclonal Clone #3A1.891.3 |
| Applications: | IHC, WB |
![Western Blot: ABCA1 Antibody (3A1.891.3) [NB400-164]](https://resources.bio-techne.com/images/products/ABCA1-Antibody-3A1-891-3-Western-Blot-NB400-164-img0008.jpg "Western Blot: ABCA1 Antibody (3A1.891.3) [NB400-164]")
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #1276B |
| Applications: | IHC, WB, ICC/IF, Flow |
![Western Blot: ABCA1 Antibody (1276B)BSA Free [NBP2-54792]](https://resources.bio-techne.com/images/products/ABCA1-Antibody-1276B-Western-Blot-NBP2-54792-img0001.jpg "Western Blot: ABCA1 Antibody (1276B)BSA Free [NBP2-54792]")
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #1276B |
| Applications: | WB |
| Applications: | AC, B/N |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #768510 |
| Applications: | CyTOF-ready, ICFlow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Kappa Monoclonal Clone #5A1-1422.11 |
| Applications: | Flow, WB (-) |
![Flow Cytometry: ABCA1 Antibody (5A1-1422.11) - BSA Free [NB400-165]](https://resources.bio-techne.com/images/products/ABCA1-Antibody-5A1-1422-11-Flow-Cytometry-NB400-165-img0004.jpg "Flow Cytometry: ABCA1 Antibody (5A1-1422.11) - BSA Free [NB400-165]")
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | CyTOF-ready, ICC, ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #768510 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #768510 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #768510 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #768510 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #768510 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #768510 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #768510 |
| Applications: | ICFlow |
| Applications: | ELISA |
| Applications: | WB, ELISA, MA, AP |
![SDS-PAGE: Recombinant Human ABCA1 GST (N-Term) Protein [H00000019-Q01]](https://resources.bio-techne.com/images/products/Recombinant-Human-ABCA1-Protein-SDS-Page-H00000019-Q01-img0001.jpg "SDS-PAGE: Recombinant Human ABCA1 GST (N-Term) Protein [H00000019-Q01]")
| Applications: | ELISA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #HJ1 |
| Applications: | IHC, WB, ICC/IF, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | ICC/IF |
![Immunocytochemistry/ Immunofluorescence: ABCA1 Antibody [NBP2-58550]](https://resources.bio-techne.com/images/products/ABCA1-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-58550-img0001.jpg "Immunocytochemistry/ Immunofluorescence: ABCA1 Antibody [NBP2-58550]")
| Applications: | ELISA |
| Applications: | ELISA |
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #1276B |
| Applications: | IHC, WB, ICC/IF, Flow |