Aldehyde Dehydrogenase 1-A1/ALDH1A1 Products
Aldehyde dehydrogenases (ALDHs) are NAD(P)+-dependent enzymes that detoxify aldehydes by oxidizing them to carboxylic acids. Nineteen ALDHs are present in humans, expressed in a variety of organelles and having different substrate preferences. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid. ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea. ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development. The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells. ALDH1A1 is a major enzyme in the oxidation of acetaldehyde, a toxic metabolite of ethanol.
71 results for "Aldehyde Dehydrogenase 1-A1/ALDH1A1" in Products
71 results for "Aldehyde Dehydrogenase 1-A1/ALDH1A1" in Products
Aldehyde Dehydrogenase 1-A1/ALDH1A1 Products
Aldehyde dehydrogenases (ALDHs) are NAD(P)+-dependent enzymes that detoxify aldehydes by oxidizing them to carboxylic acids. Nineteen ALDHs are present in humans, expressed in a variety of organelles and having different substrate preferences. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid. ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea. ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development. The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells. ALDH1A1 is a major enzyme in the oxidation of acetaldehyde, a toxic metabolite of ethanol.
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, IHC, IP, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #703410 |
| Applications: | WB, Simple Western, IHC, CyTOF-reported, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #ALDH1A1/1381 |
| Applications: | IHC, WB |
![Immunohistochemistry-Paraffin: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody (ALDH1A1/1381) [NBP2-53248]](https://resources.bio-techne.com/images/products/Aldehyde-Dehydrogenase-1-A1-ALDH1A1-Antibody-ALDH1A1-1381-Immunohistochemistry-Paraffin-NBP2-53248-img0002.jpg "Immunohistochemistry-Paraffin: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody (ALDH1A1/1381) [NBP2-53248]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NBP1-89152]](https://resources.bio-techne.com/images/products/Aldehyde-Dehydrogenase-1-A1-ALDH1A1-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-89152-img0006.jpg "Immunocytochemistry/ Immunofluorescence: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NBP1-89152]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #ALDH1A1/7011R |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody (ALDH1A1/7011R) [NBP3-13880]](https://resources.bio-techne.com/images/products/Aldehyde-Dehydrogenase-1-A1-ALDH1A1-Antibody-ALDH1A1-7011R-Immunohistochemistry-Paraffin-NBP3-13880-img0001.jpg "Immunohistochemistry-Paraffin: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody (ALDH1A1/7011R) [NBP3-13880]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #ALDH1A1/7011R |
| Applications: | IHC |
| Reactivity: | Human, Mouse, Rat, Zebrafish, Feline |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NBP2-15336]](https://resources.bio-techne.com/images/products/ALDH1A1-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-15336-img0001.jpg "Immunocytochemistry/ Immunofluorescence: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NBP2-15336]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
| Reactivity: | Human, Mouse, Rat, Feline |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NBP2-15334]](https://resources.bio-techne.com/images/products/ALDH1A1-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-15334-img0001.jpg "Immunocytochemistry/ Immunofluorescence: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NBP2-15334]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #1G6 |
| Applications: | IHC, WB, ELISA, IP |
![ELISA: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody (1G6) [H00000216-M05]](https://resources.bio-techne.com/images/products/Aldehyde-Dehydrogenase-1-A1-ALDH1A1-Antibody-1G6-ELISA-H00000216-M05-img0005.jpg "ELISA: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody (1G6) [H00000216-M05]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB, ELISA |
![Immunohistochemistry-Paraffin: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NB100-2563]](https://resources.bio-techne.com/images/products/Aldehyde-Dehydrogenase-1-A1-ALDH1A1-Antibody-Immunohistochemistry-Paraffin-NB100-2563-img0006.jpg "Immunohistochemistry-Paraffin: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NB100-2563]")
| Source: | E. coli |
| Accession #: | P00352 |
| Applications: | EnzAct |
| Applications: | AC |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #M562 |
| Applications: | WB, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #5A11 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #M558 |
| Applications: | WB |
| Reactivity: | Yeast |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, IP |
![Western Blot: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NB600-914]](https://resources.bio-techne.com/images/products/Aldehyde-Dehydrogenase-1-A1-ALDH1A1-Antibody-Western-Blot-NB600-914-img0001.jpg "Western Blot: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody [NB600-914]")
| Applications: | ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #8F1-R |
| Applications: | WB, ICC/IF, Flow |
| Applications: | WB |
![Western Blot: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Overexpression Lysate [NBL1-07451]](https://resources.bio-techne.com/images/products/ALDH1A1-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-07451-img0002.jpg "Western Blot: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Overexpression Lysate [NBL1-07451]")
| Applications: | ELISA |
ALDH1A1 inhibitor
| Alternate Names: | CM 037 |
| Chemical Name: | Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate |
| Purity: | ≥97% (HPLC) |
Potent and selective ALDH1A1 inhibitor
| Chemical Name: | 8-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-1H-purine-2,6-dione hydrochloride |
| Purity: | ≥98% (HPLC) |
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