ARK5/NUAK1 Products
AMPK-related kinase 5 (ARK5), also known as NUAK1, is a 74 kDa intracellular Ser/Thr kinase that promotes cell survival during nutrient deprivation and TNF family ligand-induced apoptosis. ARK5 is activated by Akt, NDR2, and LKB1-mediated phosphorylation at multiple serine and threonine residues. It inhibits the activation of Caspase-6, Caspase-8, and myosin phosphatases but promotes the activation of MMP2 and MMP9. ARK5 overexpression in several cancers contributes to increased tumor progression and aggressiveness. ARK5 contains one catalytic domain (aa 65-306), and a short isoform of the human protein is prematurely truncated within this domain.
6 results for "ARK5/NUAK1" in Products
6 results for "ARK5/NUAK1" in Products
ARK5/NUAK1 Products
AMPK-related kinase 5 (ARK5), also known as NUAK1, is a 74 kDa intracellular Ser/Thr kinase that promotes cell survival during nutrient deprivation and TNF family ligand-induced apoptosis. ARK5 is activated by Akt, NDR2, and LKB1-mediated phosphorylation at multiple serine and threonine residues. It inhibits the activation of Caspase-6, Caspase-8, and myosin phosphatases but promotes the activation of MMP2 and MMP9. ARK5 overexpression in several cancers contributes to increased tumor progression and aggressiveness. ARK5 contains one catalytic domain (aa 65-306), and a short isoform of the human protein is prematurely truncated within this domain.
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #715901 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | ELISA, ICC/IF, Flow |
![Immunocytochemistry/ Immunofluorescence: ARK5/NUAK1 Antibody [NBP1-36937]](https://resources.bio-techne.com/images/products/ARK5-NUAK1-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-36937-img0001.jpg "Immunocytochemistry/ Immunofluorescence: ARK5/NUAK1 Antibody [NBP1-36937]")
| Applications: | WB, ELISA, MA, AP |
| Reactivity: | Human |
| Details: | Mouse IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: ARK5/NUAK1 Antibody [H00009891-B01P]](https://resources.bio-techne.com/images/products/ARK5-NUAK1-Antibody-Western-Blot-H00009891-B01P-img0004.jpg "Western Blot: ARK5/NUAK1 Antibody [H00009891-B01P]")
Potent and selective NUAK1 inhibitor
| Chemical Name: | 5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one |
| Purity: | ≥98% (HPLC) |
Potent and selective NUAK1/2 inhibitor
| Chemical Name: | N-3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide |
| Purity: | ≥98% (HPLC) |
