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ARK5/NUAK1 Products

AMPK-related kinase 5 (ARK5), also known as NUAK1, is a 74 kDa intracellular Ser/Thr kinase that promotes cell survival during nutrient deprivation and TNF family ligand-induced apoptosis. ARK5 is activated by Akt, NDR2, and LKB1-mediated phosphorylation at multiple serine and threonine residues. It inhibits the activation of Caspase-6, Caspase-8, and myosin phosphatases but promotes the activation of MMP2 and MMP9. ARK5 overexpression in several cancers contributes to increased tumor progression and aggressiveness. ARK5 contains one catalytic domain (aa 65-306), and a short isoform of the human protein is prematurely truncated within this domain.

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9 results for "ARK5/NUAK1" in Products

9 results for "ARK5/NUAK1" in Products

ARK5/NUAK1 Products

AMPK-related kinase 5 (ARK5), also known as NUAK1, is a 74 kDa intracellular Ser/Thr kinase that promotes cell survival during nutrient deprivation and TNF family ligand-induced apoptosis. ARK5 is activated by Akt, NDR2, and LKB1-mediated phosphorylation at multiple serine and threonine residues. It inhibits the activation of Caspase-6, Caspase-8, and myosin phosphatases but promotes the activation of MMP2 and MMP9. ARK5 overexpression in several cancers contributes to increased tumor progression and aggressiveness. ARK5 contains one catalytic domain (aa 65-306), and a short isoform of the human protein is prematurely truncated within this domain.

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Applications: WB
Reactivity: Human, Mouse, Rat
Applications: ELISA, ICC/IF, Flow
Reactivity: Human
Applications: WB, ELISA, MA, AP
Applications: WB, ELISA, MA, AP
Applications: WB, ICC/IF
Reactivity: Human
Applications: WB
Reactivity: Human, Rat
Applications: WB

Potent and selective NUAK1 inhibitor

Potent and selective NUAK1/2 inhibitor

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