ATM Products
Germline mutations in the Ataxia Telangiectasia-mutated (ATM) gene lead to the multi-symptom disorder A-T (Ataxia Telangiectasia). Immunodeficiency, neurodegeneration, premature aging, sensitivity to ionizing radiation, and a predisposition to certain types of cancer characterize A-T. The protein product of the gene mutated in A-T is a large protein kinase involved in cell cycle checkpoint and genotoxic stress responses. The ATM protein kinase exists as a dimer in the cell nucleus. Changes in DNA structure induced by genotoxic stress lead to activation of ATM and phosphorylation of S1981 in trans. Once S1981 is phosphorylated, the dimer dissociates and active ATM monomers signal to downstream targets.
110 results for "ATM" in Products
110 results for "ATM" in Products
ATM Products
Germline mutations in the Ataxia Telangiectasia-mutated (ATM) gene lead to the multi-symptom disorder A-T (Ataxia Telangiectasia). Immunodeficiency, neurodegeneration, premature aging, sensitivity to ionizing radiation, and a predisposition to certain types of cancer characterize A-T. The protein product of the gene mutated in A-T is a large protein kinase involved in cell cycle checkpoint and genotoxic stress responses. The ATM protein kinase exists as a dimer in the cell nucleus. Changes in DNA structure induced by genotoxic stress lead to activation of ATM and phosphorylation of S1981 in trans. Once S1981 is phosphorylated, the dimer dissociates and active ATM monomers signal to downstream targets.
| Reactivity: | Human, Mouse, Rat, Monkey, Hamster - Cricetulus (Chinese Hamster) |
| Details: | Mouse IgG1 Monoclonal Clone #2C1 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +6 More |
![Immunohistochemistry-Paraffin: ATM Antibody (2C1) [NB100-309]](https://resources.bio-techne.com/images/products/ATM-Antibody-2C1-Immunohistochemistry-Paraffin-NB100-309-img0011.jpg "Immunohistochemistry-Paraffin: ATM Antibody (2C1) [NB100-309]")
| Reactivity: | Human, Mouse, Rat, Canine, Kangaroo |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +2 More |
![Western Blot: ATM Antibody [NB100-104]](https://resources.bio-techne.com/images/products/ATM-Antibody-Western-Blot-NB100-104-img0009.jpg "Western Blot: ATM Antibody [NB100-104]")
| Reactivity: | Human, Mouse, Rat, Monkey, Avian - Chicken |
| Details: | Mouse IgG1 Monoclonal Clone #5C2 |
| Applications: | IHC, WB, ICC/IF, IP |
![Western Blot: ATM Antibody (5C2) [NB100-220]](https://resources.bio-techne.com/images/products/ATM-Antibody-5C2-Western-Blot-NB100-220-img0007.jpg "Western Blot: ATM Antibody (5C2) [NB100-220]")
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP, B/N |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, Simple Western |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Western Blot: ATM Antibody [NB100-678]](https://resources.bio-techne.com/images/products/ATM-Antibody-Western-Blot-NB100-678-img0003.jpg "Western Blot: ATM Antibody [NB100-678]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | ICC/IF |
![Immunocytochemistry/ Immunofluorescence: ATM Antibody [NBP2-57867]](https://resources.bio-techne.com/images/products/ATM-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-57867-img0001.jpg "Immunocytochemistry/ Immunofluorescence: ATM Antibody [NBP2-57867]")
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, IHC, ICC |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #1163B |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IP |
![Western Blot: ATM Antibody [NB100-271]](https://resources.bio-techne.com/images/products/ATM-Antibody-Western-Blot-NB100-271-img0004.jpg "Western Blot: ATM Antibody [NB100-271]")
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #664703 |
| Applications: | ICC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #S08-8H3 |
| Applications: | WB |
![Western Blot: ATM Antibody (S08-8H3) [NBP3-20086]](https://resources.bio-techne.com/images/products/ATM-Antibody-S08-8H3-Western-Blot-NBP3-20086-img0001.jpg "Western Blot: ATM Antibody (S08-8H3) [NBP3-20086]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #6P6C6 |
| Applications: | IHC, WB |
![Western Blot: ATM Antibody (6P6C6) [NBP3-15838]](https://resources.bio-techne.com/images/products/ATM-Antibody-6P6C6-Western-Blot-NBP3-15838-img0002.jpg "Western Blot: ATM Antibody (6P6C6) [NBP3-15838]")
Recombinant monoclonal antibody expressed in HEK293F cells
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #4E11 |
| Applications: | IHC, WB, ELISA, IP |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #HL1062 |
| Applications: | IHC, WB, ICC/IF |
| Applications: | ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #2C1-RB |
| Applications: | WB |
![Western Blot: ATM Antibody (2C1-RB) [NBP3-13655]](https://resources.bio-techne.com/images/products/ATM-Antibody-2C1-RB-Western-Blot-NBP3-13655-img0002.jpg "Western Blot: ATM Antibody (2C1-RB) [NBP3-13655]")
Recombinant monoclonal antibody expressed in HEK293F cells
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #3G11 |
| Applications: | IHC, ELISA, Flow |
| Applications: | WB, ELISA, MA, AP, PAGE |
![SDS-PAGE: Recombinant Human ATM GST (N-Term) Protein [H00000472-P01]](https://resources.bio-techne.com/images/products/Recombinant-Human-ATM-Protein-SDS-Page-H00000472-P01-img0001.jpg "SDS-PAGE: Recombinant Human ATM GST (N-Term) Protein [H00000472-P01]")
| Applications: | WB, ELISA, MA, AP, PAGE |
![SDS-PAGE: Recombinant Human ATM GST (N-Term) Protein [H00000472-Q01]](https://resources.bio-techne.com/images/products/Recombinant-Human-ATM-Protein-SDS-Page-H00000472-Q01-img0001.jpg "SDS-PAGE: Recombinant Human ATM GST (N-Term) Protein [H00000472-Q01]")
Recombinant monoclonal antibody expressed in HEK293F cells
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #1C5 |
| Applications: | ELISA, ICC/IF |
![ATM [p Ser1981] Antibody (1C5)](https://resources.bio-techne.com/images/products/nbp3-26430_rabbit-atm-p-ser-1981-mab-1c5-282202412493649.jpg "Immunocytochemistry/Immunofluorescence: ATM [p Ser1981] Antibody (1C5) [NBP3-26430] -")
| Applications: | ELISA |
| Applications: | AC |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
