Bcl-6 Products
Bcl-6 (B-cell lymphoma protein 6; also ZFP51, LAZ-3 and Bcl-5) is an 80 kDa member of the Kruppel-like family of zinc finger proteins. It is expressed in germinal center B cells, neutrophils, monocytes, and immature dendritic cells, and serves as a potent transcriptional repressor of genes such as p53. Human Bcl-6 is 706 amino acids (aa) in length and contains an N-terminal BTB/POZ protein interaction domain (aa 32-99) and a series of six C2H2-type C-terminal zinc finger domains that bind DNA (aa 518-681). Centrally located are three PEST sequences (aa 336-430) that undergo phosphorylation by MAPK. This increases the molecular weight of Bcl-6 to 97 kDa and induces its degradation. Human Bcl-6 is about 99% aa identical to mouse and canine Bcl-6.
257 results for "Bcl-6" in Products
257 results for "Bcl-6" in Products
Bcl-6 Products
Bcl-6 (B-cell lymphoma protein 6; also ZFP51, LAZ-3 and Bcl-5) is an 80 kDa member of the Kruppel-like family of zinc finger proteins. It is expressed in germinal center B cells, neutrophils, monocytes, and immature dendritic cells, and serves as a potent transcriptional repressor of genes such as p53. Human Bcl-6 is 706 amino acids (aa) in length and contains an N-terminal BTB/POZ protein interaction domain (aa 32-99) and a series of six C2H2-type C-terminal zinc finger domains that bind DNA (aa 518-681). Centrally located are three PEST sequences (aa 336-430) that undergo phosphorylation by MAPK. This increases the molecular weight of Bcl-6 to 97 kDa and induces its degradation. Human Bcl-6 is about 99% aa identical to mouse and canine Bcl-6.
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #BCL6/1475 |
| Applications: | WB, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #BCL6/1718 |
| Applications: | IHC, MA |
![Immunohistochemistry-Paraffin: Bcl-6 Antibody (BCL6/1718) [NBP3-07540]](https://resources.bio-techne.com/images/products/Bcl-6-Antibody-BCL6-1718-Immunohistochemistry-Paraffin-NBP3-07540-img0002.jpg "Immunohistochemistry-Paraffin: Bcl-6 Antibody (BCL6/1718) [NBP3-07540]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #BCL6/1982 |
| Applications: | IHC, ELISA, MA |
![Immunohistochemistry-Paraffin: Bcl-6 Antibody (BCL6/1982) [NBP2-75748]](https://resources.bio-techne.com/images/products/Bcl-6-Antibody-BCL6-1982-Immunohistochemistry-Paraffin-NBP2-75748-img0001.jpg "Immunohistochemistry-Paraffin: Bcl-6 Antibody (BCL6/1982) [NBP2-75748]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #BCL6/1526 |
| Applications: | IHC, MA |
![Immunohistochemistry-Paraffin: Bcl-6 Antibody (BCL6/1526) [NBP3-07527]](https://resources.bio-techne.com/images/products/Bcl-6-Antibody-BCL6-1526-Immunohistochemistry-Paraffin-NBP3-07527-img0002.jpg "Immunohistochemistry-Paraffin: Bcl-6 Antibody (BCL6/1526) [NBP3-07527]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #BCL6/1527 |
| Applications: | IHC, MA |
![Protein Array: Bcl-6 Antibody (BCL6/1527) [NBP2-59598]](https://resources.bio-techne.com/images/products/Bcl-6-Antibody-BCL6-1527-Protein-Array-NBP2-59598-img0005.jpg "Protein Array: Bcl-6 Antibody (BCL6/1527) [NBP2-59598]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Canine |
| Details: | Rabbit IgG Monoclonal Clone #BCL6/2497R |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: Bcl-6 Antibody (BCL6/2497R) [NBP3-07563]](https://resources.bio-techne.com/images/products/Bcl-6-Antibody-BCL6-2497R-Immunohistochemistry-Paraffin-NBP3-07563-img0001.jpg "Immunohistochemistry-Paraffin: Bcl-6 Antibody (BCL6/2497R) [NBP3-07563]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rBCL6/1718 |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: Bcl-6 Antibody (rBCL6/1718) [NBP3-07509]](https://resources.bio-techne.com/images/products/Bcl-6-Antibody-rBCL6-1718-Immunohistochemistry-Paraffin-NBP3-07509-img0001.jpg "Immunohistochemistry-Paraffin: Bcl-6 Antibody (rBCL6/1718) [NBP3-07509]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rBCL6/1475 |
| Applications: | WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rBCL6/1475 |
| Applications: | WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Canine |
| Details: | Rabbit IgG Monoclonal Clone #BCL6/2497R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rBCL6/1718 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #BCL6/1982 |
| Applications: | IHC, ELISA, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #BCL6/1526 |
| Applications: | IHC, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #BCL6/1527 |
| Applications: | IHC, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #BCL6/1718 |
| Applications: | IHC, MA |
Molecular glue; induces degradation of BCL6
| Chemical Name: | rel-5-[[5-Chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunohistochemistry-Paraffin: Bcl-6 Antibody [NBP2-59786]](https://resources.bio-techne.com/images/products/Bcl-6-Antibody-Immunohistochemistry-Paraffin-NBP2-59786-img0005.jpg "Immunohistochemistry-Paraffin: Bcl-6 Antibody [NBP2-59786]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: Bcl-6 Antibody [NBP2-31369]](https://resources.bio-techne.com/images/products/Bcl6-Antibody-Western-Blot-NBP2-31369-img0003.jpg "Western Blot: Bcl-6 Antibody [NBP2-31369]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 kappa Monoclonal Clone #SPM602 |
| Applications: | IHC, ICC/IF, Flow |
![Immunohistochemistry-Paraffin: Bcl-6 Antibody (SPM602) [NBP3-07526]](https://resources.bio-techne.com/images/products/Bcl-6-Antibody-SPM602-Immunohistochemistry-Paraffin-NBP3-07526-img0001.jpg "Immunohistochemistry-Paraffin: Bcl-6 Antibody (SPM602) [NBP3-07526]")
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #CL14612 |
| Applications: | IHC, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL14611 |
| Applications: | IHC, ICC/IF |
Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
| Chemical Name: | (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid |
| Purity: | ≥98% |
| Applications: | WB, ELISA, MA, AP |
![SDS-PAGE: Recombinant Human Bcl-6 GST (N-Term) Protein [H00000604-Q01]](https://resources.bio-techne.com/images/products/Recombinant-Human-Bcl-6-Protein-SDS-Page-H00000604-Q01-img0002.jpg "SDS-PAGE: Recombinant Human Bcl-6 GST (N-Term) Protein [H00000604-Q01]")
Recombinant Monoclonal
| Reactivity: | Human |
| Details: | Rabbit Monoclonal Clone #BLR143H |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Immunoprecipitation: Bcl-6 Antibody (BLR143H) [NBP3-14723]](https://resources.bio-techne.com/images/products/Bcl-6-Antibody-Immunoprecipitation-NBP3-14723-img0001.jpg "Immunoprecipitation: Bcl-6 Antibody (BLR143H) [NBP3-14723]")