BMP-6 Products
BMP-6 (Bone Morphogenetic Protein 6) forms disulfide-linked homodimers and heterodimers with BMP-2 that signal through complexes of type I (Activin RIA/ALK-2 and BMPR-IA/ALK-3) and type II (Activin RIIA and BMPR-II) receptors. BMP-6 promotes osteoblast differentiation from mesenchymal stem cells, chondrocyte maturation, Ang II-induced aldosterone production in the adrenal cortex, and hormone production and responsiveness in ovarian granulosa cells. It promotes neurite outgrowth, neuroprotection, angiogenesis, immune tolerance, and tumor progression. BMP-6 binds to RGM-C/Hemojuvelin to enhance Hepcidin expression and prevent serum iron overload. Heterodimers of BMP-2 and BMP-6 show increased potency at inducing bone formation compared to either BMP-2 or BMP-6 homodimers.
46 results for "BMP-6" in Products
46 results for "BMP-6" in Products
BMP-6 Products
BMP-6 (Bone Morphogenetic Protein 6) forms disulfide-linked homodimers and heterodimers with BMP-2 that signal through complexes of type I (Activin RIA/ALK-2 and BMPR-IA/ALK-3) and type II (Activin RIIA and BMPR-II) receptors. BMP-6 promotes osteoblast differentiation from mesenchymal stem cells, chondrocyte maturation, Ang II-induced aldosterone production in the adrenal cortex, and hormone production and responsiveness in ovarian granulosa cells. It promotes neurite outgrowth, neuroprotection, angiogenesis, immune tolerance, and tumor progression. BMP-6 binds to RGM-C/Hemojuvelin to enhance Hepcidin expression and prevent serum iron overload. Heterodimers of BMP-2 and BMP-6 show increased potency at inducing bone formation compared to either BMP-2 or BMP-6 homodimers.
Source: | NS0 |
Accession #: | P22004 |
Applications: | BA |
Reactivity: | Human |
Details: | Mouse IgG2b Monoclonal Clone #74219 |
Applications: | WB, Neut |
Source: | CHO |
Accession #: | P20722 |
Applications: | BA |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB, IHC, Neut |
Assay Range: | 156 - 10,000 pg/mL |
Applications: | ELISA |
Source: | E. coli |
Accession #: | P12643 (BMP-2) & P22004 (BMP-6) |
Applications: | BA |
Source: | CHO |
Accession #: | Q04906.2 |
Applications: | BA |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB |
Reactivity: | Mouse |
Details: | Sheep IgG Polyclonal |
Applications: | WB, IHC |
Reactivity: | Mouse |
Details: | Rat IgG2b Monoclonal Clone #719040 |
Applications: | Neut |
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #SR1703 |
Applications: | IHC, WB, ICC/IF, Flow |
Applications: | ELISA |
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #6N5S9 |
Applications: | WB, ICC/IF |
Applications: | ELISA |
Reactivity: | Human |
Details: | Mouse IgG2a Kappa Monoclonal Clone #D4 |
Applications: | IHC, WB, ICC/IF |
Reactivity: | Human, Porcine |
Details: | Mouse IgG1 kappa Monoclonal Clone #D2 |
Applications: | IHC, WB, ICC/IF |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | ICC/IF |
Applications: | WB |
Applications: | ELISA |
Reactivity: | Human |
Details: | Mouse IgG2B Monoclonal Clone #74219.11 |
Applications: | WB, ELISA, B/N |
Applications: | AC |
Reactivity: | Human |
Details: | Mouse IgG2B Monoclonal Clone #74219.11 |
Applications: | WB, ELISA, B/N |
Reactivity: | Human |
Details: | Mouse IgG2B Monoclonal Clone #74219.11 |
Applications: | WB, ELISA, B/N |
Reactivity: | Human |
Details: | Mouse IgG2B Monoclonal Clone #74219.11 |
Applications: | WB, ELISA, B/N |