BMPR-IA/ALK-3 Products
Cellular responses to bone morphogenetic proteins (BMPs) are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. There are seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors that function in TGF-beta superfamily signal transduction. The type II receptors for TGF-beta and activin bind ligands with high affinity by themselves. In contrast, BMPR-II binding to BMP-2, BMP-4, and BMP-7 is facilitated by the presence of the type I receptor. The type I receptors are also known as activin receptor-like kinases or ALKs.
79 results for "BMPR-IA/ALK-3" in Products
79 results for "BMPR-IA/ALK-3" in Products
BMPR-IA/ALK-3 Products
Cellular responses to bone morphogenetic proteins (BMPs) are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. There are seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors that function in TGF-beta superfamily signal transduction. The type II receptors for TGF-beta and activin bind ligands with high affinity by themselves. In contrast, BMPR-II binding to BMP-2, BMP-4, and BMP-7 is facilitated by the presence of the type I receptor. The type I receptors are also known as activin receptor-like kinases or ALKs.
Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs
| Chemical Name: | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent AMPK inhibitor; also BMP type I receptor inhibitor
| Alternate Names: | Compound C,BML-275 |
| Chemical Name: | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, CyTOF-ready |
LDN 193189 synthesized to cGMP guidelines
| Chemical Name: | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
| Purity: | ≥99% |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #4B7B2 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +1 More |
![Western Blot: BMPR-IA/ALK-3 Antibody (4B7B2)BSA Free [NBP2-37421]](https://resources.bio-techne.com/images/products/BMPR-IA-ALK-3-Antibody-4B7B2-Western-Blot-NBP2-37421-img0003.jpg "Western Blot: BMPR-IA/ALK-3 Antibody (4B7B2)BSA Free [NBP2-37421]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow |
| Source: | NS0 |
| Accession #: | NP_004320 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #550607 |
| Applications: | IHC |
| Source: | NS0 |
| Accession #: | NP_033888 |
| Applications: | BA |
Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water
| Chemical Name: | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
| Purity: | ≥97% (HPLC) |
| Reactivity: | Human |
| Details: | Mouse IgG2 Monoclonal Clone #MM0053-8L7 |
| Applications: | IHC, WB |
![Immunohistochemistry: BMPR-IA/ALK-3 Antibody (MM0053-8L7) - Azide and BSA Free [NBP2-12029]](https://resources.bio-techne.com/images/products/BMPR-IA-ALK-3-Antibody-MM0053-8L7-Immunohistochemistry-NBP2-12029-img0001.jpg "Immunohistochemistry: BMPR-IA/ALK-3 Antibody (MM0053-8L7) - Azide and BSA Free [NBP2-12029]")
Type I BMP receptor inhibitor
| Chemical Name: | 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #4C4 |
| Applications: | WB, ELISA |
![Western Blot: BMPR-IA/ALK-3 Antibody (4C4) [H00000657-M01]](https://resources.bio-techne.com/images/products/BMPR-IA-ALK-3-Antibody-4C4-Western-Blot-H00000657-M01-img0002.jpg "Western Blot: BMPR-IA/ALK-3 Antibody (4C4) [H00000657-M01]")
| Source: | NS0 |
| Accession #: | CAA80257 |
| Applications: | BA |
| Applications: | ELISA |
| Applications: | ELISA |
| Source: | NS0 |
| Accession #: | Q60607 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA |
![Western Blot: BMPR-IA/ALK-3 Antibody [NB100-41375]](https://resources.bio-techne.com/images/products/BMPR-IA-ALK-3-Antibody-Western-Blot-NB100-41375-img0003.jpg "Western Blot: BMPR-IA/ALK-3 Antibody [NB100-41375]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: BMPR-IA/ALK-3 Antibody [NBP2-15601]](https://resources.bio-techne.com/images/products/BMPR-IA-ALK-3-Antibody-Western-Blot-NBP2-15601-img0003.jpg "Western Blot: BMPR-IA/ALK-3 Antibody [NBP2-15601]")
| Applications: | ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Mouse |
| Details: | Rabbit IgG Monoclonal Clone #002 |
| Applications: | ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Mouse |
| Details: | Rabbit IgG Monoclonal Clone #002 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2 Monoclonal Clone #MM0053-8L7 |
| Applications: | IHC, WB |