BMPR-IB/ALK-6 Products
Cellular responses to bone morphogenetic proteins (BMPs) are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. There are seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors that function in TGF-beta superfamily signal transduction. The type II receptors for TGF-beta and activin bind ligands with high affinity by themselves. In contrast, BMPR-II binding to BMP-2, BMP-4, and BMP-7 is facilitated by the presence of the type I receptor. The type I receptors are also known as activin receptor-like kinases or ALKs.
89 results for "BMPR-IB/ALK-6" in Products
89 results for "BMPR-IB/ALK-6" in Products
BMPR-IB/ALK-6 Products
Cellular responses to bone morphogenetic proteins (BMPs) are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. There are seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors that function in TGF-beta superfamily signal transduction. The type II receptors for TGF-beta and activin bind ligands with high affinity by themselves. In contrast, BMPR-II binding to BMP-2, BMP-4, and BMP-7 is facilitated by the presence of the type I receptor. The type I receptors are also known as activin receptor-like kinases or ALKs.
Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs
| Chemical Name: | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
| Purity: | ≥98% |
Potent AMPK inhibitor; also BMP type I receptor inhibitor
| Alternate Names: | Compound C,BML-275 |
| Chemical Name: | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Monoclonal Clone #88614 |
| Applications: | WB |
| Source: | NS0 |
| Accession #: | O00238 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow, CyTOF-ready, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Source: | NS0 |
| Accession #: | P36898 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow |
| Reactivity: | Human, Mouse, Rat, Bovine |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: BMPR-IB/ALK-6 Antibody [NBP2-14889]](https://resources.bio-techne.com/images/products/BMPR-IB-ALK-6-Antibody-Western-Blot-NBP2-14889-img0009.jpg "Western Blot: BMPR-IB/ALK-6 Antibody [NBP2-14889]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #477914 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2 Monoclonal Clone #MM0055-3E12 |
| Applications: | IHC, WB |
![Immunohistochemistry-Paraffin: BMPR-IB/ALK-6 Antibody (MM0055-3E12) - Azide and BSA Free [NBP2-12031]](https://resources.bio-techne.com/images/products/BMPR-IB-ALK-6-Antibody-MM0055-3E12-Immunohistochemistry-Paraffin-NBP2-12031-img0001.jpg "Immunohistochemistry-Paraffin: BMPR-IB/ALK-6 Antibody (MM0055-3E12) - Azide and BSA Free [NBP2-12031]")
Type I BMP receptor inhibitor
| Chemical Name: | 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #2E2 |
| Applications: | WB, ELISA |
![Western Blot: BMPR-IB/ALK-6 Antibody (2E2) [H00000658-M07]](https://resources.bio-techne.com/images/products/BMPR-IB-ALK-6-Antibody-2E2-Western-Blot-H00000658-M07-img0004.jpg "Western Blot: BMPR-IB/ALK-6 Antibody (2E2) [H00000658-M07]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #2F3 |
| Applications: | WB, ELISA, KD |
![Western Blot: BMPR-IB/ALK-6 Antibody (2F3) [H00000658-M01]](https://resources.bio-techne.com/images/products/BMPR-IB-ALK-6-Antibody-2F3-Western-Blot-H00000658-M01-img0006.jpg "Western Blot: BMPR-IB/ALK-6 Antibody (2F3) [H00000658-M01]")
Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water
| Chemical Name: | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
| Purity: | ≥97% (HPLC) |
