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Calreticulin Products

Calreticulin is a multifunctional, intracellular calcium-binding protein that is found in most eukaryotic cells. It serves as a key regulator of intracellular free calcium levels. Calreticulin also functions as a lectin-type chaperone in the endoplasmic reticulum (ER). It binds to oligosaccharide residues on newly synthesized glycoproteins to ensure proper folding and retains non-native protein conformers within the ER where they are targeted for degradation. Calreticulin has also been characterized as an inhibitor of steroid hormone-regulated gene expression. Its N-terminal domain, which is termed Vasostatin, binds to the KxFFKR motif located in the DNA-binding domain of nuclear hormone receptors, preventing the receptors from binding to their specific recognition sequence. Additionally, Calreticulin is thought to function as an extracellular lectin and an intracellular mediator of integrin-dependent cell adhesion. Calreticulin-2, an isoform of calreticulin, is expressed in testis, while calreticulin is expressed more widely. The two isoforms of human calreticulin share 53% sequence identity.

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213 results for "Calreticulin" in Products

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213 results for "Calreticulin" in Products

Calreticulin Products

Calreticulin is a multifunctional, intracellular calcium-binding protein that is found in most eukaryotic cells. It serves as a key regulator of intracellular free calcium levels. Calreticulin also functions as a lectin-type chaperone in the endoplasmic reticulum (ER). It binds to oligosaccharide residues on newly synthesized glycoproteins to ensure proper folding and retains non-native protein conformers within the ER where they are targeted for degradation. Calreticulin has also been characterized as an inhibitor of steroid hormone-regulated gene expression. Its N-terminal domain, which is termed Vasostatin, binds to the KxFFKR motif located in the DNA-binding domain of nuclear hormone receptors, preventing the receptors from binding to their specific recognition sequence. Additionally, Calreticulin is thought to function as an extracellular lectin and an intracellular mediator of integrin-dependent cell adhesion. Calreticulin-2, an isoform of calreticulin, is expressed in testis, while calreticulin is expressed more widely. The two isoforms of human calreticulin share 53% sequence identity.

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Applications: IHC, WB, ELISA, ICC/IF, Flow, Func
Reactivity: Human, Mouse
Applications: IHC, WB, ICC/IF, Flow, IP, B/N, DB, KD, MA, MS, Simple Western
Reactivity: Human, Mouse, Rat, Bovine, Primate, +1 More
Applications: ICFlow
Reactivity: Human
Applications: ICFlow
Reactivity: Human
Applications: WB, IHC, ICFlow, KO
Reactivity: Human, Mouse, Rat
Applications: IHC, WB, ICC/IF, Simple Western, KO, KD
Reactivity: Human, Mouse
Applications: ICFlow
Reactivity: Human
Applications: ICFlow
Reactivity: Human
Catalog #: NBP3-15404
Applications: IHC, IP, WB
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: WB, IHC
Reactivity: Human
Applications: IHC, WB, ICC/IF
Reactivity: Human, Mouse, Rat
Applications: ICFlow
Reactivity: Human
Applications: IHC, WB
Reactivity: Human, Mouse, Rat
Applications: WB, ELISA, ICC/IF, Flow
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ICFlow
Reactivity: Human
Applications: ICFlow
Reactivity: Human
Applications: IHC, WB, ICC/IF, IP
Reactivity: Human, Primate
Applications: ELISA
Applications: ELISA
Applications: IHC, WB, ICC/IF, IP
Reactivity: Human, Mouse, Rat, Canine
Applications: WB
Reactivity: Human
Applications: IHC, WB, ICC/IF, Flow, IP, B/N, DB, KD, MA, MS, Simple Western
Reactivity: Human, Mouse, Rat, Bovine, Primate, +1 More
Applications: ELISA
Applications: WB, ELISA
Reactivity: Human
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