CD177: Proteins and Enzymes

CD177 is polymorphic and has at least two alleles, PRV1 and NB1. Human PRV1 is a 55-65 kDa, glycosyl-phosphotidylinositol (GPI) linked glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is expressed by neutrophils and neutrophil precursors, and changes in expression serve as diagnostic markers for myeloproliferative disorde...