Skip to main content

CDK2 Products

CDK2 (cyclin-dependent kinase 2), a serine/threonine protein kinase, is the catalytic subunit of the heterodimeric cyclin-dependent kinase complex required for G1/S phase transition. The kinase activity of CDK2 is regulated by the association with a cyclin subunit, CDK inhibitors, and its phosphorylation state. The active CDK2/cyclin A complex interacts with the N-terminus of E2F-1 and directs the phosphorylation of E2F-1 and DP-1. The active CDK2/cyclin E complex phosphorylates Rb which disrupts its binding to E2F, allowing E2F activation and transcription of the genes necessary for S-phase entry and progression. Inhibition of the CDK2/cyclin complex can be attributed to its association with p21Waf1/Cip1 and p27Kip1 and the phosphorylation of CDK2 on Thr14 and Tyr15. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Tyr14 and Tyr15.

Show More

85 results for "CDK2" in Products

Back to Search Results
Apply

85 results for "CDK2" in Products

CDK2 Products

CDK2 (cyclin-dependent kinase 2), a serine/threonine protein kinase, is the catalytic subunit of the heterodimeric cyclin-dependent kinase complex required for G1/S phase transition. The kinase activity of CDK2 is regulated by the association with a cyclin subunit, CDK inhibitors, and its phosphorylation state. The active CDK2/cyclin A complex interacts with the N-terminus of E2F-1 and directs the phosphorylation of E2F-1 and DP-1. The active CDK2/cyclin E complex phosphorylates Rb which disrupts its binding to E2F, allowing E2F activation and transcription of the genes necessary for S-phase entry and progression. Inhibition of the CDK2/cyclin complex can be attributed to its association with p21Waf1/Cip1 and p27Kip1 and the phosphorylation of CDK2 on Thr14 and Tyr15. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Tyr14 and Tyr15.

Show More
Applications: IHC, WB, ICC/IF, Flow
Reactivity: Human, Mouse, Rat, Canine, Monkey
Applications: WB, Simple Western, IHC, ICC
Reactivity: Human, Mouse, Rat
Applications: IHC, WB, ELISA, ICC/IF, Flow, CyTOF-ready
Reactivity: Human, Mouse
Applications: IHC, WB, IP
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody.

Applications: IHC, WB, ICC/IF
Reactivity: Human
Applications: WB, ELISA, Flow, IP, CyTOF-ready
Reactivity: Human, Mouse, Xenopus, Frog - Xenopus (African Clawed Frog)
Applications: IHC, WB, IP
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: IHC, WB, ELISA
Reactivity: Human, Mouse, Rat
Applications: WB, KO
Reactivity: Human, Bovine, Fish
Applications: IHC, WB, ELISA, ICC/IF
Reactivity: Xenopus
Applications: IHC, WB
Reactivity: Human
Applications: WB, ELISA
Reactivity: Human, Rat
Applications: IHC, WB, ELISA, IP
Reactivity: Human

Recombinant monoclonal antibody expressed in HEK293F cells

Applications: IHC, WB, ELISA
Reactivity: Human, Mouse

Recombinant monoclonal antibody expressed in HEK293F cells

Applications: WB, KO
Reactivity: Human, Mouse, Rat
Applications: PAGE
Applications: IHC, WB, ICC/IF, Flow, CyTOF-ready
Reactivity: Human, Mouse, Rat, Canine, Monkey
Applications: IHC, WB, ICC/IF, Flow, CyTOF-ready
Reactivity: Human, Mouse, Rat, Canine, Monkey
Applications: IHC, WB, ICC/IF, Flow, CyTOF-ready
Reactivity: Human, Mouse, Rat, Canine, Monkey
Applications: IHC, WB, ELISA, ICC/IF
Reactivity: Xenopus
Applications: IHC, WB, ELISA, ICC/IF
Reactivity: Xenopus
Applications: IHC, WB, ICC/IF, Flow, CyTOF-ready
Reactivity: Human, Mouse, Rat, Canine, Monkey
Catalog #: NBP2-88911CL1
Applications: IHC, WB, ICC/IF
Reactivity: Human
Applications: IHC, WB, ICC/IF
Reactivity: Human
Applications: IHC, WB, ICC/IF
Reactivity: Human
Results Per Page
5 10 25 50
/ 4