Complement C3 Products
Both elevated levels and reduced levels of Complement C3 has been implicated in diseases pathologies (6). Deficiency in Complement proteins can result in autoimmune disorders including systemic lupus erythematosus, which is more often associated with C1 or C4 deficiency and only rarely with C3 deficiency (6). However, C3 deficiency typically results in increased risk of recurrent bacterial infections and glomerulonephritis, characterized by inflammation of the filtering glomeruli in the kidneys (6). Additionally, elevated levels of C3a and C4a is seen in patients with antiphospholipid antibody syndrome (6). Serum levels of C3 are also higher in rheumatoid arthritis cases (6). The complement system has become a target for drugs and therapeutics aimed at modulating innate immunity (7). For instance, compstatin is a peptide that binds to C3, inhibiting convertase activity and cleavage and can be used to treat diseases associated with uncontrolled C3 activation (7). C3-inhibitors and other complement inhibitors are a promising drug candidate for treatment of many diseases (7).
References
1. Mathern, D. R., & Heeger, P. S. (2015). Molecules Great and Small: The Complement System. Clinical Journal of the American Society of Nephrology: CJASN. https://doi.org/10.2215/CJN.06230614
2. Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015). Complement System Part I - Molecular Mechanisms of Activation and Regulation. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2015.00262
3. Ricklin, D., Reis, E. S., Mastellos, D. C., Gros, P., & Lambris, J. D. (2016). Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense. Immunological Reviews. https://doi.org/10.1111/imr.12500
4. Merle, N. S., Noe, R., Halbwachs-Mecarelli, L., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015). Complement System Part II: Role in Immunity. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2015.00257
5. Sahu, A., & Lambris, J. D. (2001). Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunological Reviews. https://doi.org/10.1034/j.1600-065x.2001.1800103.x
6. Vignesh, P., Rawat, A., Sharma, M., & Singh, S. (2017). Complement in autoimmune diseases. Clinica Chimica Acta; International Journal of Clinical Chemistry. https://doi.org/10.1016/j.cca.2016.12.017
7. Mastellos, D. C., Yancopoulou, D., Kokkinos, P., Huber-Lang, M., Hajishengallis, G., Biglarnia, A. R., Lupu, F., Nilsson, B., Risitano, A. M., Ricklin, D., & Lambris, J. D. (2015). Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. European Journal of Clinical Investigation. https://doi.org/10.1111/eci.12419
83 results for "Complement C3" in Products
83 results for "Complement C3" in Products
Complement C3 Products
Both elevated levels and reduced levels of Complement C3 has been implicated in diseases pathologies (6). Deficiency in Complement proteins can result in autoimmune disorders including systemic lupus erythematosus, which is more often associated with C1 or C4 deficiency and only rarely with C3 deficiency (6). However, C3 deficiency typically results in increased risk of recurrent bacterial infections and glomerulonephritis, characterized by inflammation of the filtering glomeruli in the kidneys (6). Additionally, elevated levels of C3a and C4a is seen in patients with antiphospholipid antibody syndrome (6). Serum levels of C3 are also higher in rheumatoid arthritis cases (6). The complement system has become a target for drugs and therapeutics aimed at modulating innate immunity (7). For instance, compstatin is a peptide that binds to C3, inhibiting convertase activity and cleavage and can be used to treat diseases associated with uncontrolled C3 activation (7). C3-inhibitors and other complement inhibitors are a promising drug candidate for treatment of many diseases (7).
References
1. Mathern, D. R., & Heeger, P. S. (2015). Molecules Great and Small: The Complement System. Clinical Journal of the American Society of Nephrology: CJASN. https://doi.org/10.2215/CJN.06230614
2. Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015). Complement System Part I - Molecular Mechanisms of Activation and Regulation. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2015.00262
3. Ricklin, D., Reis, E. S., Mastellos, D. C., Gros, P., & Lambris, J. D. (2016). Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense. Immunological Reviews. https://doi.org/10.1111/imr.12500
4. Merle, N. S., Noe, R., Halbwachs-Mecarelli, L., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015). Complement System Part II: Role in Immunity. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2015.00257
5. Sahu, A., & Lambris, J. D. (2001). Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunological Reviews. https://doi.org/10.1034/j.1600-065x.2001.1800103.x
6. Vignesh, P., Rawat, A., Sharma, M., & Singh, S. (2017). Complement in autoimmune diseases. Clinica Chimica Acta; International Journal of Clinical Chemistry. https://doi.org/10.1016/j.cca.2016.12.017
7. Mastellos, D. C., Yancopoulou, D., Kokkinos, P., Huber-Lang, M., Hajishengallis, G., Biglarnia, A. R., Lupu, F., Nilsson, B., Risitano, A. M., Ricklin, D., & Lambris, J. D. (2015). Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. European Journal of Clinical Investigation. https://doi.org/10.1111/eci.12419
Reactivity: | Mouse, E. coli, Bacteria - Escherichia coli |
Details: | Rat IgG2A Monoclonal Clone #11H9 |
Applications: | IHC, WB, ICC/IF, ELISA, Flow, +3 More |
Applications: | ELISA |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, ICC/IF, IP, Simple Western |
Recombinant Monoclonal Antibody.
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #JF10-30 |
Applications: | IHC, WB, ICC/IF, Flow |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC |
Applications: | ELISA, NULL |
Applications: | ELISA |
Recombinant monoclonal antibody expressed in HEK293F cells
Reactivity: | Human |
Details: | Rabbit IgG Monoclonal Clone #4D12 |
Applications: | IHC, WB, ELISA, Flow |
Reactivity: | Human |
Details: | Mouse IgG2a Kappa Monoclonal Clone #5F9 |
Applications: | IHC, WB, ELISA |
Applications: | WB, ELISA, MA, AP |
Reactivity: | Human |
Details: | Mouse IgG2a Kappa Monoclonal Clone #X1 |
Applications: | WB, ELISA |
Recombinant monoclonal antibody expressed in HEK293F cells
Reactivity: | Human |
Details: | Rabbit IgG Monoclonal Clone #8C3 |
Applications: | IHC, ELISA |
Applications: | ELISA |
Applications: | AC |
Applications: | AC |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Human IgG1 Monoclonal Clone #NGM621 |
Applications: | ELISA, Flow, Func |
Applications: | ELISA |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #F1-8 |
Applications: | ELISA, IP, AP |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #F1-8 |
Applications: | ELISA, IP, AP |
Reactivity: | Mouse, E. coli |
Details: | Rat IgG2A Monoclonal Clone #11H9 |
Applications: | IHC, ELISA, ICC/IF, Flow, IP, +1 More |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Human IgG1 Monoclonal Clone #NGM621 |
Applications: | ELISA, Flow, Func |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Human IgG1 Monoclonal Clone #NGM621 |
Applications: | ELISA, Flow, Func |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Human IgG1 Monoclonal Clone #NGM621 |
Applications: | ELISA, Flow, Func |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Human IgG1 Monoclonal Clone #NGM621 |
Applications: | ELISA, Flow, Func |