Crossveinless-2/CV-2 Products

Crossveinless-2 (CV-2), also known as bone morphogenetic protein-binding endothelial cell precursor-derived regulator (BMPER), is a secreted Chordin-like protein that modulates the BMP signaling pathway. Human CV-2 is synthesized as a 685 amino acid (aa) precursor protein with a putative 39 aa signal peptide, five tandem Chordin-like, cysteine-rich domains, a partial von Willebrand factor type D domain (vWD), and a carboxy terminal-trypsin inhibitor-like cysteine-rich domain (TIL). Secreted CV-2 is reported to be proteolytically cleaved to generate two fragments that are disulfide-linked.