CRYBA4: Proteins and Enzymes

CRYBA4, or Beta-crystallin A4, consists of a 196 amino acid isoform that is 22 kDa, and is involved in maintaining the structure, transparency, and refractive index of the eye lens. Current disease research has linked defects in CRYBA4 to several types of cataracts, including lamellar 2 cataracts, zonular cataract, congenital cataracts, and microphthalmia cataract. Researchers are also studying the relation between the protein and the disorders choroididits and neurofibromatosis. CRYBA4 is included in several biological processes, including visual perception and camera-type eye development, through which it interacts with CRYBB2 and CRYBB3.