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DPPIV/CD26 Products

DPPIV/CD26 is a serine exopeptidase that is expressed as a noncovalent homodimer on the surface of epithelial cells, endothelial cells, and activated lymphocytes. It regulates multiple aspects of immune and endocrine function by cleaving Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of a wide variety of chemokines (CCL4 and 5, CXCL6, 9, 10, 11, and 12), growth factors (GM-CSF, IL-3), and peptide hormones (Glucagon, Glucagon-like Peptides 1 and 2, GIP, GHRH, Procalcitonin, Neuropeptide Y, and Substance P).

DPPIV interacts in cis with Adenosine Deaminase on T cells, in trans with Caveolin-1 on antigen presenting cells, and it serves as a cell entry coreceptor for HIV and coronavirus. It provides costimulatory proliferation and activation signals to both CD4+ and CD8+ T cells. A soluble form of DPPIV can be proteolytically shed from adipocytes, leading to insulin resistance in adipocytes and skeletal muscle.

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259 results for "DPPIV/CD26" in Products

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259 results for "DPPIV/CD26" in Products

DPPIV/CD26 Products

DPPIV/CD26 is a serine exopeptidase that is expressed as a noncovalent homodimer on the surface of epithelial cells, endothelial cells, and activated lymphocytes. It regulates multiple aspects of immune and endocrine function by cleaving Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of a wide variety of chemokines (CCL4 and 5, CXCL6, 9, 10, 11, and 12), growth factors (GM-CSF, IL-3), and peptide hormones (Glucagon, Glucagon-like Peptides 1 and 2, GIP, GHRH, Procalcitonin, Neuropeptide Y, and Substance P).

DPPIV interacts in cis with Adenosine Deaminase on T cells, in trans with Caveolin-1 on antigen presenting cells, and it serves as a cell entry coreceptor for HIV and coronavirus. It provides costimulatory proliferation and activation signals to both CD4+ and CD8+ T cells. A soluble form of DPPIV can be proteolytically shed from adipocytes, leading to insulin resistance in adipocytes and skeletal muscle.

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Applications: WB, Simple Western, IHC, ICC
Reactivity: Human
Applications: WB, Simple Western, IHC
Reactivity: Mouse
Applications: EnzAct
Applications: IHC, WB, ICC/IF, Flow, KO
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: WB, Flow, CyTOF-ready
Reactivity: Human
Applications: IHC, WB, ICC/IF
Reactivity: Human, Monkey, Primate
Applications: IHC, ELISA, Flow
Reactivity: Human, Rat
Applications: IHC, ICC/IF, Flow, IP
Reactivity: Human, Rat
Applications: BA, EnzAct

Biotinylated

Applications: IHC, WB, ICC/IF, Flow
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
Reactivity: Mouse
Applications: Flow
Reactivity: Mouse
Applications: WB
Reactivity: Human
Applications: Flow, CyTOF-ready
Reactivity: Mouse
Applications: Flow
Reactivity: Mouse
Applications: WB, IP
Reactivity: Mouse
Applications: Flow
Reactivity: Mouse
Applications: Flow
Reactivity: Mouse
Applications: Flow
Reactivity: Human
Applications: Flow, CyTOF-ready
Reactivity: Mouse
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