GFI1B Products

The GFI1B gene codes for a zinc finger protein Gfi-1b. Isoform 1 (p37) is 330 amino acids in length at around 37 kDA while isoform 2 (p32) is 284 amino acids long at approximately 32 kDA. GFI1B is essential in transcriptional regulation which is critical for the development and differentiation of erythroid and magakaryocytic lineages. Research is investigating the role of GFI1B in aplastic anemia, ataxia, chronic leukemia, anemia, neutropenia, and hematopoiesis. This gene has interacted with JAG2, BRE, LTBP4, EFEMP1, and EFEMP2 to contribute to pathways of lymphocyte signaling.