GPR35: cDNA Clones

GPR35 is a rhodopsin-like G protein-coupled receptor (GPCR). GPR35 isoform B, also known as GPR35B, is longer at the N-terminus, compared to isoform A. Kynurenic acid, a tryptophan metabolite, and 2-acyl lysophosphatidic acid may act as endogenous ligands for GPR35. Human iNKT cells express GPR35 which is functionally active in reducing IL-4 release.