IL-17E/IL-25 Products
IL-17E/IL-25 (Interleukin-25) is a cytokine that promotes Th2-biased immune responses. This is in contrast to other IL-17 family members which promote Th1- and Th17-biased inflammation. IL-25 is an important mediator of allergic reactions and protection against intestinal parasites. During helminth infections and allergic reactions, IL-25 is locally upregulated in intestinal and airway epithelial cells, atopic dermatitis skin lesions, and local Th2 cells, eosinophils, and basophils. It binds to IL-17 RB but also requires IL-17 RA to exert its activity. IL-25 acts on a variety of cell types which respond with increased production of Th2 cytokines (e.g. IL-4, IL-5, IL-13) and reduced production of Th1 and Th17 cytokines (e.g. IFN-gamma, IL-12, IL-23, IL-17A, IL-17F). Airway IL-25 can be activated by MMP-7, a protease that is upregulated in airway epithelium in response to allergen exposure. Cleaved IL-25 shows enhanced binding to IL-17 RB and stronger induction of Th2 cytokines. IL-25 also promotes vascular endothelial cell proliferation and assembly into tubular structures. It supports the integrity of the blood-brain barrier and limits CD4+ T cell infiltration into the brain.
263 results for "IL-17E/IL-25" in Products
263 results for "IL-17E/IL-25" in Products
IL-17E/IL-25 Products
IL-17E/IL-25 (Interleukin-25) is a cytokine that promotes Th2-biased immune responses. This is in contrast to other IL-17 family members which promote Th1- and Th17-biased inflammation. IL-25 is an important mediator of allergic reactions and protection against intestinal parasites. During helminth infections and allergic reactions, IL-25 is locally upregulated in intestinal and airway epithelial cells, atopic dermatitis skin lesions, and local Th2 cells, eosinophils, and basophils. It binds to IL-17 RB but also requires IL-17 RA to exert its activity. IL-25 acts on a variety of cell types which respond with increased production of Th2 cytokines (e.g. IL-4, IL-5, IL-13) and reduced production of Th1 and Th17 cytokines (e.g. IFN-gamma, IL-12, IL-23, IL-17A, IL-17F). Airway IL-25 can be activated by MMP-7, a protease that is upregulated in airway epithelium in response to allergen exposure. Cleaved IL-25 shows enhanced binding to IL-17 RB and stronger induction of Th2 cytokines. IL-25 also promotes vascular endothelial cell proliferation and assembly into tubular structures. It supports the integrity of the blood-brain barrier and limits CD4+ T cell infiltration into the brain.
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
Applications: | ELISA |
Contains 4 membranes - each spotted in duplicate with 36 different cytokine antibodies
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #IL25/625 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #IL25/625 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #IL25/625 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #IL25/625 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #IL25/625 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #IL25/625 |
Applications: | IHC |
Source: | E. coli |
Accession #: | NP_542767 |
Applications: | BA |
Source: | NS0 |
Accession #: | NP_542767 |
Applications: | BA |
Source: | HEK293 |
Accession #: | Q9H293 |
Applications: | BA |
Assay Range: | 62.5 - 4,000 pg/mL |
Applications: | ELISA |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #182203 |
Applications: | WB, ELISA, CyTOF-ready, ICFlow |
Reactivity: | Human, Mouse |
Details: | Mouse IgG1 Monoclonal Clone #68C1039.2 |
Applications: | IHC, WB, ICC/IF |
Reactivity: | Mouse |
Details: | Goat IgG Polyclonal |
Applications: | WB |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #182203 |
Applications: | ICFlow |
Assay Range: | 11.7 - 750 pg/mL |
Applications: | ELISA |
Reactivity: | Mouse |
Details: | Goat IgG Polyclonal |
Applications: | WB |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB, ELISA, Neut |
Reactivity: | Mouse |
Details: | Rat IgG2b Monoclonal Clone #207702 |
Applications: | CyTOF-ready, ICFlow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #182203 |
Applications: | ICFlow |
Reactivity: | Mouse |
Details: | Rat IgG2b Monoclonal Clone #207710 |
Applications: | WB |