IL-27 Products

IL-27 is a heterodimeric cytokine that is composed of EBI3 (which is related to the p40 subunit of IL-12 and IL-23) and p28 (which is related to the p35 chain of IL-12). IL-27 is expressed by monocytes, endothelial cells, and dendritic cells. It signals through a receptor complex composed of IL-27 R alpha/WSX-1/TCCR and gp130. IL-27 induces IL-12 receptor expression on naïve CD4⁺ T cells, sensitizing them to subsequent IL-12-induced Th1 development. It also functions as an anti-inflammatory cytokine by limiting T and NKT cell activity.

Products:

• Primary Antibodies
• Proteins & Enzymes
• Luminex Assays
• Proteome Profiler Antibody Arrays
• cDNA Clones
• ELISAs