LPP: Proteins and Enzymes

Human LIM domain-containing preferred translocation partner in lipoma (LPP) is an 80 kDa intracellular protein that contains an N-terminal Pro-rich region (aa 41-370) followed by three tandem LIM domains (aa 414-603). It localizes to focal adhesion plaques where it regulates junction assembly and cytoskeleton remodeling through interactions with alpha-Actinin, VASP, SCRIB, Supervillin, and Palladin. In the nucleus, LPP coactivates the transcription factor PEA3 and protects telomeres from DNA damage. LPP is a frequent target of chromosomal translocations with HMG-A2 in lipoma.