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NF-L Products

Neurofilaments are intermediate filaments that are major components of the neuronal cytoskeleton. Neurofilaments are composed of three subunits: the heavy subunit (NF-H), medium subunit (NF-M), and light subunit (NF-L). Neurofilaments are trimers that always contain the 68 kDa NF-L and variably contain 125 kDa NF-M and 200 kDa NF-H. The human neurofilament heavy chain is a phosphorylated cytoskeletal intermediate filament protein that is expressed in neurons. The neurofilament medium subunit Human NF-M is a phosphorylated glycoprotein that belongs to the type IV intermediate filament family. NF-L is a 68 kDa light chain cytoskeletal intermediate filament protein that associates with the 125 kDa NF-M and the 200 kDa NF-H to form neurofilaments.

All three neurofilament subunits share a common structure, with globular head, alpha-helical rod, and carboxy terminal side-arm domains. The subunits assemble to form 10 nm neurofilaments. Accumulation of neurofilaments is seen in several human diseases including amyotrophic lateral sclerosis (ALS), Parkinsons disease, Alzheimers disease, and diabetic neuropathy.

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219 results for "NF-L" in Products

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219 results for "NF-L" in Products

NF-L Products

Neurofilaments are intermediate filaments that are major components of the neuronal cytoskeleton. Neurofilaments are composed of three subunits: the heavy subunit (NF-H), medium subunit (NF-M), and light subunit (NF-L). Neurofilaments are trimers that always contain the 68 kDa NF-L and variably contain 125 kDa NF-M and 200 kDa NF-H. The human neurofilament heavy chain is a phosphorylated cytoskeletal intermediate filament protein that is expressed in neurons. The neurofilament medium subunit Human NF-M is a phosphorylated glycoprotein that belongs to the type IV intermediate filament family. NF-L is a 68 kDa light chain cytoskeletal intermediate filament protein that associates with the 125 kDa NF-M and the 200 kDa NF-H to form neurofilaments.

All three neurofilament subunits share a common structure, with globular head, alpha-helical rod, and carboxy terminal side-arm domains. The subunits assemble to form 10 nm neurofilaments. Accumulation of neurofilaments is seen in several human diseases including amyotrophic lateral sclerosis (ALS), Parkinsons disease, Alzheimers disease, and diabetic neuropathy.

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Applications: Simple Plex

Build your own multi-plex biomarker immunoassay panel for Ella™. Highly precise and reproducible. Choose from more than 250 fully validated target analytes.

Applications: IHC, ICC/IF, Flow
Reactivity: Human, Rat, Bovine, Porcine, Chicken
Applications: IHC, ICC/IF, Flow
Reactivity: Human, Rat, Bovine, Porcine, Chicken
Applications: IHC, ICC/IF, Flow
Reactivity: Human, Rat, Bovine, Porcine, Chicken
Applications: IHC, ICC/IF, Flow
Reactivity: Human, Rat, Bovine, Porcine, Chicken
Applications: Simple Plex

Simple Plex Mouse NFL assay kit contains cartridge, sample diluent SD13, and wash buffer. Part # starting with ST01 ships in 2-3 days. Sample type indicated with MP (Plasma/Serum).

Applications: Ctrl, Simple Plex

Control for use with Human, Mouse, and NHP NF-L Simple Plex Cartridge Kits

Simple Plex 32x2 panel containing GFAP 2nd Gen and NF-L with sample diluent SD13, and wash buffer. Part # starting with ST01 ships in 3-5 days. Sample type indicated with PS (Plasma/Serum).

Applications: Simple Plex

Simple Plex Non-Human Primate NF-L assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.

Applications: IHC, WB, ICC/IF, KO
Reactivity: Human, Mouse, Rat, Bovine, Porcine
Applications: IHC, WB, ICC/IF, ELISA, Flow, CyTOF-ready
Reactivity: Human
Applications: IHC, WB, ICC/IF, Simple Western
Reactivity: Human, Mouse, Rat, Bovine, Mammal, +1 More
Applications: Simple Plex

Simple Plex Rat NF-L assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.

Applications: WB, IHC, ICC
Reactivity: Human, Mouse, Rat
Applications: WB, IHC, Dual ISH-IHC, ICC
Reactivity: Human
Applications: IHC, WB, ICC/IF
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: WB, IHC, Dual ISH-IHC
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Applications: IHC, WB, ICC/IF, ELISA, Flow, CyTOF-ready
Reactivity: Human
Applications: ConfAbSpec, ICC
Reactivity: Human
Applications: IHC, Dual ISH-IHC, ICC
Reactivity: Human
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