Norrin Products
Norrin (also called Norrie Disease Protein or NDP) is a secreted regulatory protein, mutations in which cause Norrie disease (X-linked retinal dysplasia). Norrin consists of disulfide-linked homodimers that oligomerize further via disulfide bridges to form higher order oligomers containing up to ten units of 12 kDa each. Molecular modeling studies predict that Norrin assumes a cysteine-knot structure typical for the TGF-beta family. Although Norrin is not related to Wnt family proteins, it functions like a Wnt protein in that it binds with high affinity to the receptor Frizzled-4, requires LDL receptor-related protein (LRP) as a co-receptor, and induces activation of the canonical Wnt signaling pathway.
70 results for "Norrin" in Products
70 results for "Norrin" in Products
Norrin Products
Norrin (also called Norrie Disease Protein or NDP) is a secreted regulatory protein, mutations in which cause Norrie disease (X-linked retinal dysplasia). Norrin consists of disulfide-linked homodimers that oligomerize further via disulfide bridges to form higher order oligomers containing up to ten units of 12 kDa each. Molecular modeling studies predict that Norrin assumes a cysteine-knot structure typical for the TGF-beta family. Although Norrin is not related to Wnt family proteins, it functions like a Wnt protein in that it binds with high affinity to the receptor Frizzled-4, requires LDL receptor-related protein (LRP) as a co-receptor, and induces activation of the canonical Wnt signaling pathway.
| Source: | E. coli |
| Accession #: | Q00604 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Block |
| Source: | E. coli |
| Accession #: | P48744 |
| Applications: | BA |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #343711 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: Norrin/NDP AntibodyBSA Free [NBP1-77014]](https://resources.bio-techne.com/images/products/Norrin-NDP-Antibody-Western-Blot-NBP1-77014-img0004.jpg "Western Blot: Norrin/NDP AntibodyBSA Free [NBP1-77014]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: Norrin/NDP Antibody [NBP1-59305]](https://resources.bio-techne.com/images/products/Norrin-NDP-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-59305-img0005.jpg "Immunocytochemistry/ Immunofluorescence: Norrin/NDP Antibody [NBP1-59305]")
| Reactivity: | Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Applications: | AC |
| Applications: | WB |
![Western Blot: Norrin/NDP Overexpression Lysate [NBL1-13528]](https://resources.bio-techne.com/images/products/NDP-Norrin-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-13528-img0002.jpg "Western Blot: Norrin/NDP Overexpression Lysate [NBL1-13528]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Norrin/NDP Antibody Immunocytochemistry/Immunofluorescence: Norrin/NDP Antibody [NBP1-84769]](https://resources.bio-techne.com/images/products/nbp1-84769_rabbit-polyclonal-norrin-ndp-antibody-163202412121612.jpg "Immunocytochemistry/Immunofluorescence: Norrin/NDP Antibody [NBP1-84769]")
| Applications: | PAGE |
![SDS-PAGE: Recombinant Human Norrin/NDP His Protein [NBP2-23294]](https://resources.bio-techne.com/images/products/Recombinant-Human-Norrin-NDP-His-Protein-SDS-Page-NBP2-23294-img0002.jpg "SDS-PAGE: Recombinant Human Norrin/NDP His Protein [NBP2-23294]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Applications: | AC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |