PERK Products

PERK, a type 1 endoplasmic reticulum (ER) membrane kinase, mediates eIF2 alpha phosphorylation at Ser51 during the UPR (unfolded protein response). Protein synthesis is inhibited, thereby reducing the burden of protein substrate for the ER folding and degradation mechanism. Phosphorylation of eIF2 alpha by PERK also selectively promotes the expr...