PIB5PA: Proteins and Enzymes

PIB5PA, also referred to as Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A, has a long isoform that is 1,006 amino acids in length and 107 kDa, and two shorter isoforms that are 639 and 638 amino acids long. It is known that PIB5PA converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate, and it is thought that PIB5PA may mediate the function of plasma membrane proteins. Research is currently being conducted on PIB5PA in relation to several diseases and disorders including breast cancer, Guillain-Barre syndrome, developmental disorders and Autoimmune Lymphoproliferative Syndrome. PIB5PA has also been shown to have interactions with INPP1, PTEN, ITPK1, INPP4A and ITPKA in pathways such as lipid metabolism and lipoprotein metabolism.