PSENEN Products
Gamma-secretase subunit PSENEN, also called PEN2 (Presenilin enhancer protein 2) is a 10 kDa member of the PEN2 family. Human PSENEN is 101 amino acids (aa) in length, and is a multipass transmembrane protein. Human PSENEN shares 96% aa sequence identity with mouse and rat PSENEN. Functionally, PSENEN is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and beta-amyloid precursor protein.
17 results for "PSENEN" in Products
17 results for "PSENEN" in Products
PSENEN Products
Gamma-secretase subunit PSENEN, also called PEN2 (Presenilin enhancer protein 2) is a 10 kDa member of the PEN2 family. Human PSENEN is 101 amino acids (aa) in length, and is a multipass transmembrane protein. Human PSENEN shares 96% aa sequence identity with mouse and rat PSENEN. Functionally, PSENEN is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and beta-amyloid precursor protein.
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #JE41-28 |
| Applications: | IHC, WB, ICC/IF, Flow |
![Western Blot: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632]](https://resources.bio-techne.com/images/products/PSENEN-PEN2-Antibody-JE41-28-Western-Blot-NBP2-75632-img0009.jpg "Western Blot: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #665521 |
| Applications: | IHC |
| Reactivity: | Human, Mouse, Rat, Canine, Bovine, +2 More |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: PSENEN/PEN2 Antibody [NBP2-24611]](https://resources.bio-techne.com/images/products/PSENEN-PEN2-Antibody-Western-Blot-NBP2-24611-img0002.jpg "Western Blot: PSENEN/PEN2 Antibody [NBP2-24611]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, IP |
![Western Blot: PSENEN/PEN2 Antibody [NB300-227]](https://resources.bio-techne.com/images/products/PEN2-Antibody-Western-Blot-NB300-227-img0003.jpg "Western Blot: PSENEN/PEN2 Antibody [NB300-227]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #6J5O4 |
| Applications: | WB, ICC/IF |
![Western Blot: PSENEN/PEN2 Antibody (6J5O4) [NBP3-16676]](https://resources.bio-techne.com/images/products/PSENEN-PEN2-Antibody-6J5O4-Western-Blot-NBP3-16676-img0002.jpg "Western Blot: PSENEN/PEN2 Antibody (6J5O4) [NBP3-16676]")
| Applications: | WB, ELISA, MA, AP |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: PSENEN/PEN2 Antibody [NBP2-47319]](https://resources.bio-techne.com/images/products/PSENEN-PEN2-Antibody-Immunohistochemistry-Paraffin-NBP2-47319-img0004.jpg "Immunohistochemistry-Paraffin: PSENEN/PEN2 Antibody [NBP2-47319]")
| Applications: | WB |
![Western Blot: PSENEN/PEN2 Overexpression Lysate [NBL1-14862]](https://resources.bio-techne.com/images/products/PEN2-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-14862-img0002.jpg "Western Blot: PSENEN/PEN2 Overexpression Lysate [NBL1-14862]")
| Applications: | AC |
γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester |
| Purity: | ≥99% (HPLC) |
DAPT synthesized to Ancillary Material Grade
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester |
| Purity: | ≥99% |
γ-secretase inhibitor; inhibits Notch pathway
| Alternate Names: | Dibenzazepine,YO-01027 |
| Chemical Name: | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| Purity: | ≥98% (HPLC) |
Potent γ-secretase inhibitor
| Chemical Name: | (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide |
| Purity: | ≥98% (HPLC) |
γ-secretase inhibitor; attenuates amyloid plaque deposition
| Chemical Name: | N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide |
| Purity: | ≥99% (HPLC) |
Highly potent γ-secretase inhibitor; orally bioavailable
| Alternate Names: | BMS-708163 |
| Chemical Name: | (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide |
| Purity: | ≥98% (HPLC) |
Potent γ-secretase inhibitor
| Chemical Name: | 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid |
| Purity: | ≥98% (HPLC) |
γ-secretase pseudo-inhibitor
| Chemical Name: | (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide |
| Purity: | ≥98% (HPLC) |
