Pygopus-1: Lysates
Pygopus-1 and -2 are nuclear transcription co-activators. Structurally they are characterized by an N-terminal homology domain and C-terminal PHD (plant homeodomain) finger Zn2+-binding domain. The PHD finger binds to legless/Bcl9, which in turn binds beta-catenin, a downstream mediator of Wnt signaling. This complex binds TCF/LEF DNA binding proteins. Formation of the quaternary complex is required for the activation of Wnt-responsive genes.
1 result for "Pygopus-1 Lysates" in Products
1 result for "Pygopus-1 Lysates" in Products
Pygopus-1: Lysates
Pygopus-1 and -2 are nuclear transcription co-activators. Structurally they are characterized by an N-terminal homology domain and C-terminal PHD (plant homeodomain) finger Zn2+-binding domain. The PHD finger binds to legless/Bcl9, which in turn binds beta-catenin, a downstream mediator of Wnt signaling. This complex binds TCF/LEF DNA binding proteins. Formation of the quaternary complex is required for the activation of Wnt-responsive genes.
| Applications: | WB |
![Western Blot: Pygopus-1 Overexpression Lysate [NBP2-07146]](https://resources.bio-techne.com/images/products/PYGO1-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-07146-img0001.jpg "Western Blot: Pygopus-1 Overexpression Lysate [NBP2-07146]")