R-Spondin 3 Products
R-Spondin 3 (RSPO3; Cristin 1) is a secreted Wnt regulating protein that is critical for the development of the placental labyrinthine layer. It is expressed in the roof plate, tail, somites, otic vesicles, cephalic mesoderm, truncus arteriosus, atrioventricular canal of the developing heart, and strongly but transiently in developing limbs.
R-Spondins regulate Wnt/β-catenin by competing with the Wnt antagonist DKK-1 for binding to the Wnt co-receptors LRP-6 and Kremen, reducing their DKK-1-mediated internalization. Reports differ on whether R-Spondins bind LRP-6 directly.
Products:
110 results for "R-Spondin 3" in Products
110 results for "R-Spondin 3" in Products
R-Spondin 3 Products
R-Spondin 3 (RSPO3; Cristin 1) is a secreted Wnt regulating protein that is critical for the development of the placental labyrinthine layer. It is expressed in the roof plate, tail, somites, otic vesicles, cephalic mesoderm, truncus arteriosus, atrioventricular canal of the developing heart, and strongly but transiently in developing limbs.
R-Spondins regulate Wnt/β-catenin by competing with the Wnt antagonist DKK-1 for binding to the Wnt co-receptors LRP-6 and Kremen, reducing their DKK-1-mediated internalization. Reports differ on whether R-Spondins bind LRP-6 directly.
Products:
Analyzed by SEC-MALS
| Source: | CHO |
| Accession #: | Q9BXY4 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | Q2TJ95 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | Q9BXY4.1 |
| Applications: | BA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3D5 |
| Applications: | IHC |
![Immunohistochemistry: R-Spondin 3 Antibody (OTI3D5) [NBP2-45637]](https://resources.bio-techne.com/images/products/R-Spondin-3-Antibody-3D5-Immunohistochemistry-NBP2-45637-img0015.jpg "Immunohistochemistry: R-Spondin 3 Antibody (OTI3D5) [NBP2-45637]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1028231 |
| Applications: | ELISA |
| Assay Range: | 9.38 - 600 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Rat IgG2b Monoclonal Clone #400403 |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #400404 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | Neut |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1028220 |
| Applications: | ELISA |
| Source: | HEK293 |
| Accession #: | XP_005551811.1 |
| Applications: | BA |
| Assay Range: | 15.6 - 1,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Source: | CHO |
| Accession #: | Q9BXY4.1 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | Q2TJ95.2 |
| Applications: | BA |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: R-Spondin 3 AntibodyBSA Free [NBP2-81849]](https://resources.bio-techne.com/images/products/R-Spondin-3-Antibody-Western-Blot-NBP2-81849-img0002.jpg "Western Blot: R-Spondin 3 AntibodyBSA Free [NBP2-81849]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: R-Spondin 3 Antibody [NBP1-82234]](https://resources.bio-techne.com/images/products/R-Spondin-3-Antibody-Immunohistochemistry-Paraffin-NBP1-82234-img0008.jpg "Immunohistochemistry-Paraffin: R-Spondin 3 Antibody [NBP1-82234]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #rosmantuzumab |
| Applications: | ELISA, Flow, Func |
| Applications: | WB |
![Western Blot: R-Spondin 3 Overexpression Lysate [NBL1-15602]](https://resources.bio-techne.com/images/products/RSPO3-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-15602-img0002.jpg "Western Blot: R-Spondin 3 Overexpression Lysate [NBL1-15602]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #rosmantuzumab |
| Applications: | ELISA, Flow, Func |
| Applications: | AC |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |