TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
449 results for "TIM-3" in Products
449 results for "TIM-3" in Products
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
![Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) [NBP2-79702]](https://resources.bio-techne.com/images/products/TIM-3-Antibody-TIM3-3113-Immunohistochemistry-Paraffin-NBP2-79702-img0003.jpg "Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) [NBP2-79702]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-ready, Dual ISH-IHC, +1 More |
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
| Applications: | Simple Plex |
| Sensitivity: | 8.75 pg/mL |
| Applications: | ELISA |
| Assay Range: | 31.3 - 2,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
Simple Plex Human TIM-3 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Source: | NS0 |
| Accession #: | Q8TDQ0 |
| Applications: | Bind |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2321C |
| Applications: | WB, Flow, IHC, CyTOF-ready |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-reported |
Biotinylated
| Source: | CHO |
| Accession #: | AAH63431.1 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-ready |
| Source: | CHO |
| Accession #: | AAL65157.1 |
| Applications: | BA |
Clone F38-2E2 was used by HLDA to establish CD designation.
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #F38-2E2 |
| Applications: | Flow |
![Flow Cytometry: TIM-3 Antibody (F38-2E2) - BSA Free [NBP2-27220]](https://resources.bio-techne.com/images/products/TIM-3-Antibody-F38-2E2-Flow-Cytometry-NBP2-27220-img0002.jpg "Flow Cytometry: TIM-3 Antibody (F38-2E2) - BSA Free [NBP2-27220]")
| Reactivity: | Human |
| Details: | Rat IgG1 Monoclonal Clone #344801 |
| Applications: | AgAct |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #215008 |
| Applications: | Flow |
For use with catalog number DTIM30
| Applications: | Ctrl |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Source: | NS0 |
| Accession #: | P0C0K5.2 |
| Applications: | BA |
