UBE2G2: Proteins and Enzymes

Ubiquitin-conjugating Enzyme E2G 2 (UBE2G2), also known as Ubiquitin-conjugating Enzyme 7 (Ubc7), is a ubiquitously expressed member of the Ubiquitin-conjugating (E2) enzyme family that localizes to both the nucleus and cytoplasm. UBE2G2 has a predicted molecular weight of 18 kDa. The human protein shares 100% amino acid sequence identity with the mouse and rat orthologs. UBE2G2 interacts with the HRD1 and gp78 Ubiquitin ligases (E3s) to mediate efficient endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins in human cells. Mechanistically, it has been shown that UBE2G2 forms Lys48-linked Ubiquitin chains on itself prior to gp78-dependent transfer of the Ubiquitin chains to target proteins. UBE2G2 also interacts with the CRL4(Cdt2) E3 complex to promote the ubiquitination and degradation of Cdt1 following UV irradiation, suggesting that UBE2G2 may function in the response to DNA damage.