VAMP-8: Proteins and Enzymes

VAMP-8 (vesicle associated membrane protein 8; also endobrevin) is a 12 kDa member of the synaptobrevin family of proteins. A type IV transmembrane (TM) protein (i.e.- a type II TM protein whose C-terminus is predominately transmembrane), VAMP-8 is found in cells involved in vesicle release (platelets, mast cells and pancreatic acinar cells). VAMP-8 regulates exocytosis and decouples granule release from cytokine release. Human VAMP-8 is 100 amino acids (aa) in length. It contains a vSNARE coiled-coil homology region (aa 12 - 72) and a membrane-anchor domain (aa 76 - 96).