5-HT4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14526

Novus Biologicals, part of Bio-Techne
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NBP3-14526
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bat (90%), Canine (95%), Equine (100%), Monkey (100%), Porcine (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

1 mg/ml

View all 5-HT4 Antibodies »

Product Specifications

Immunogen

Synthetic 20 amino acid peptide from C-Terminus of human 5HT4.

Epitope

C-Terminus

Reactivity Notes

Expected reactivity based on percent sequence identity: Guinea pig (85%), Mouse, Rat (80%)

Specificity

Human 5-HT4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for 5-HT4 Antibody

Immunohistochemistry-Paraffin: 5-HT4 Antibody [NBP3-14526]

Immunohistochemistry-Paraffin: 5-HT4 Antibody [NBP3-14526]

Immunohistochemistry-Paraffin: 5-HT4 Antibody [NBP3-14526] - Immunohistochemistry of formalin-fixed, paraffin-embedded human brain vessel after heat-induced antigen retrieval.

Applications for 5-HT4 Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: 5-HT4

The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop. 5-HT4 receptor expression has been documented primarily in the brain, and in colon, heart, and vessel. An EST has been isolated from a human cancerous nerve library.

Long Name

5-Hydroxytryptamine Receptor 4

Alternate Names

5HT4, HTR4

Gene Symbol

HTR4

Additional 5-HT4 Products

Product Documents for 5-HT4 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for 5-HT4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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