Activin RIB/ALK-4 Antibody (S08-8D6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19558

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19558-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S08-8D6

Concentration

0.3 mg/ml

View all Activin RIB/ALK-4 Antibodies »

Product Summary for Activin RIB/ALK-4 Antibody (S08-8D6)

Immunogen

A synthetic peptide of human Activin RIB/ALK-4 (Uniprot # P36896)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Activin RIB/ALK-4 Antibody (S08-8D6)

Western Blot: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558]

Western Blot: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558]

Western Blot: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558] - Western blot detection of Activin RIB/ALK-4 in CHO-K1 (Lane 1), Rat Brain (Lane 2) lysates using NBP3-19558 (1:500 diluted). Predicted band size: 57kDa. Observed band size: 57kDa.
Immunocytochemistry/ Immunofluorescence: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558]

Immunocytochemistry/ Immunofluorescence: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558]

Immunocytochemistry/Immunofluorescence: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558] - Immunofluorescence of Activin RIB/ALK-4 (green) in hela using NBP3-19558 at dilution 1/50, and DAPI (blue)

Applications for Activin RIB/ALK-4 Antibody (S08-8D6)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1/20-1/50

Western Blot

1/1000-1/5000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Activin RIB/ALK-4

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

Long Name

Activin Receptor IB

Alternate Names

ActivinRIB, ACVR1B, ALK-4, ALK4

Gene Symbol

ACVR1B

Additional Activin RIB/ALK-4 Products

Product Documents for Activin RIB/ALK-4 Antibody (S08-8D6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Activin RIB/ALK-4 Antibody (S08-8D6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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