Adrenomedullin R/ADMR/GPR182 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90231

Novus Biologicals, part of Bio-Techne
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NBP1-90231
NBP1-90231-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Adrenomedullin R/ADMR Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Adrenomedullin R/ADMR/GPR182 Antibody

Western Blot: Adrenomedullin R/ADMR/GPR182 Antibody [NBP1-90231]

Western Blot: Adrenomedullin R/ADMR/GPR182 Antibody [NBP1-90231]

Western Blot: Adrenomedullin R/ADMR/GPR182 Antibody [NBP1-90231] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-20
Immunohistochemistry-Paraffin: Adrenomedullin R/ADMR/GPR182 Antibody [NBP1-90231]

Immunohistochemistry-Paraffin: Adrenomedullin R/ADMR/GPR182 Antibody [NBP1-90231]

Immunohistochemistry-Paraffin: Adrenomedullin R/ADMR/GPR182 Antibody [NBP1-90231] - Staining of human spleen shows high expression.
Immunohistochemistry-Paraffin: Adrenomedullin R/ADMR/GPR182 Antibody [NBP1-90231]

Immunohistochemistry-Paraffin: Adrenomedullin R/ADMR/GPR182 Antibody [NBP1-90231]

Immunohistochemistry-Paraffin: Adrenomedullin R/ADMR/GPR182 Antibody [NBP1-90231] - Staining of human heart muscle shows strong positivity of intercalated discs.
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Applications for Adrenomedullin R/ADMR/GPR182 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Adrenomedullin R/ADMR

G Protein-Coupled Receptor L1/G10D has been suggested to be an Adrenomedullin Receptor. Originally cloned from rats and later from humans, L1/G10D does not to bind adrenomedullin or display functional cAMP response to adrenomedullin (reviewed in Poyner et al. 2002). The initial experimental results, which demonstrated high-affinity binding and increased levels of cAMP in COS cells that were transfected with L1/G10D and treated with adrenomedullin, could not be reproduced by other laboratories (Kapas et al. 1995). It is now known that the functional adrenomedullin receptor is a heterodimeric complex composed of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) (McLatchie et al. 1998). L1/G10D therefore should be considered an Orphan A receptor. L1/G10D expression has been reported in adrenal gland, bone marrow, brain, heart, kidney, liver, lung, lymph node, pancreas, skeletal muscle, small intestine, spleen, stomach, testis, and thyroid. ESTs have been isolated from kidney, liver/spleen, fetal lung/testis/B-cell, and melanocyte/uterus/fetal heart libraries.

Long Name

Adrenomedullin Receptor

Alternate Names

7TMR, ADMR, AdrenomedullinR, AMR, G10D, GAMRH, Gpcr22, GPR182, MB10, NOW

Gene Symbol

GPR182

Additional Adrenomedullin R/ADMR Products

Product Documents for Adrenomedullin R/ADMR/GPR182 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Adrenomedullin R/ADMR/GPR182 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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