ALK/CD246 Antibody (RM361)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-77424

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP2-77424
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM361

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ALK/CD246 Antibodies »

Product Specifications

Immunogen

A peptide corresponding to the C-terminus of human ALK/CD246 (Anaplastic lymphoma kinase)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ALK/CD246 Antibody (RM361)

Western Blot: ALK/CD246 Antibody (RM361) [NBP2-77424]

Western Blot: ALK/CD246 Antibody (RM361) [NBP2-77424]

Western Blot: ALK/CD246 Antibody (RM361) [NBP2-77424] - Western Blot of NSCLC cell line H2228 (Cell Lysate) expressing EML4-ALK variant 3, using NBP2-77424.
Immunohistochemistry: ALK/CD246 Antibody (RM361) [NBP2-77424]

Immunohistochemistry: ALK/CD246 Antibody (RM361) [NBP2-77424]

Immunohistochemistry: ALK/CD246 Antibody (RM361) [NBP2-77424] - Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using NBP2-77424.
Immunohistochemistry: ALK/CD246 Antibody (RM361) [NBP2-77424]

Immunohistochemistry: ALK/CD246 Antibody (RM361) [NBP2-77424]

Immunohistochemistry: ALK/CD246 Antibody (RM361) [NBP2-77424] - Immunohistochemical staining of formalin fixed and paraffin embedded NCI-H2228 cells (expressing EML4-ALK variant 3) and Daudi cells (ALK negative), stained with anti-ALK rabbit monoclonal antibody NBP2-77424.

Applications for ALK/CD246 Antibody (RM361)

Application
Recommended Usage

Immunohistochemistry

1:500-1:1000

Western Blot

1:1000 - 1:2000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ALK/CD246

ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was shown to fuse the NPM nucleolar phosphoprotein gene on chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on chromosome 2p23 (1). In the predicted hybrid protein, the amino terminus of NPM is linked to the catalytic domain of ALK. Immunoblotting with anti-ALK antibody shows that ALK is highly expressed in the neonatal brain (2). Also expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas (3).

Long Name

Anaplastic Lymphoma Kinase

Alternate Names

CD246, Ki-1, Tcrz

Gene Symbol

ALK

Additional ALK/CD246 Products

Product Documents for ALK/CD246 Antibody (RM361)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ALK/CD246 Antibody (RM361)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.