B7-1/CD80 Antibody (16-10A1) - Low Endotoxin, Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-05756

Novus Biologicals, part of Bio-Techne
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NBP3-05756
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Key Product Details

Species Reactivity

Validated:

Mouse, Canine

Applications

Flow Cytometry, Functional, Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Hamster IgG2 Clone # 16-10A1

Format

Low Endotoxin, Azide and BSA Free

Concentration

1 mg/ml

View all B7-1/CD80 Antibodies »

Product Summary for B7-1/CD80 Antibody (16-10A1) - Low Endotoxin, Azide and BSA Free

Immunogen

CD80-transfected CHO cell line

Clonality

Monoclonal

Host

Hamster

Isotype

IgG2

Scientific Data Images for B7-1/CD80 Antibody (16-10A1) - Low Endotoxin, Azide and BSA Free

Flow Cytometry: B7-1/CD80 Antibody (16-10A1) - Low Endotoxin, Azide and BSA Free [NBP3-05756]

Flow Cytometry: B7-1/CD80 Antibody (16-10A1) - Low Endotoxin, Azide and BSA Free [NBP3-05756]

Flow Cytometry: B7-1/CD80 Antibody (16-10A1) - Low Endotoxin and Azide Free [NBP3-05756] - Flow cytometry surface staining pattern of murine peritoneal fluid cell suspension stained using Hamster Monoclonal B7-1/CD80 Antibody (16-10A1) (concentration in sample 2 ug/ml).

Applications for B7-1/CD80 Antibody (16-10A1) - Low Endotoxin, Azide and BSA Free

Application
Recommended Usage

Flow Cytometry

1-4 ug/ml
Application Notes
Functional application: Blocking
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

Low endotoxin azide free PBS solution, 0.2 um filter sterilized.

Format

Low Endotoxin, Azide and BSA Free

Preservative

No Preservative

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: B7-1/CD80

The B-lymphocyte activation antigen B7-1 (CD80) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines (1). The relatively small CTLA-4/B7-1 binding interface exhibits an unusually high degree of shape complementarity. CTLA-4 forms homodimers through a newly defined interface of highly conserved residues. This zipper-like oligomerization provides the structural basis for forming unusually stable signalling complexes at the T-cell surface, underscoring the importance of potent inhibitory signalling in human immune responses (2).

Alternate Names

B71, CD80

Gene Symbol

CD80

Additional B7-1/CD80 Products

Product Documents for B7-1/CD80 Antibody (16-10A1) - Low Endotoxin, Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for B7-1/CD80 Antibody (16-10A1) - Low Endotoxin, Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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