Bcl-xL Antibody (042) [DyLight 488]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-90348G

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Product Datasheet / COA / SDS

Recombinant Monoclonal Antibody

View Available Conjugates

Conjugate

Catalog #

Unconjugated

NBP2-90348

Alexa Fluor 350

NBP2-90348AF350

Alexa Fluor 405

NBP2-90348AF405

Alexa Fluor 488

NBP2-90348AF488

Alexa Fluor 532

NBP2-90348AF532

Alexa Fluor 594

NBP2-90348AF594

Alexa Fluor 647

NBP2-90348AF647

Alexa Fluor 700

NBP2-90348AF700

Alexa Fluor 750

NBP2-90348AF750

Allophycocyanin

NBP2-90348APC

Biotin

NBP2-90348B

CoraFluor 1

NBP2-90348CL1

DyLight 350

NBP2-90348UV

DyLight 405

NBP2-90348V

DyLight 550

NBP2-90348R

DyLight 594

NBP2-90348DL594

DyLight 650

NBP2-90348C

DyLight 680

NBP2-90348FR

DyLight 755

NBP2-90348IR

FITC

NBP2-90348F

HRP

NBP2-90348H

Janelia Fluor 525

NBP2-90348JF525

Janelia Fluor 549

NBP2-90348JF549

Janelia Fluor 585

NBP2-90348JF585

Janelia Fluor 635

NBP2-90348JF635

Janelia Fluor 646

NBP2-90348JF646

Janelia Fluor 669

NBP2-90348JF669

mFluor Violet 450 SE

NBP2-90348MFV450

mFluor Violet 500 SE

NBP2-90348MFV500

mFluor Violet 610 SE

NBP2-90348MFV610

PE

NBP2-90348PE

PerCP

NBP2-90348PCP

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Mouse

Applications

ELISA

Label

DyLight 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 042

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Bcl-xL Antibodies »

Product Summary for Bcl-xL Antibody (042) [DyLight 488]

Immunogen

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Bcl-xL (Uniprot#: Q64373-1; Met1-Arg212).

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for Bcl-xL Antibody (042) [DyLight 488]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Bcl-xL

Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis (1). Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2 (2). It has been found that eterodimerization with Bax does not seem to be required for anti-apoptotic activity (3). Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerization-independent cell survival (4). The Bcl-X(S) isoform promotes apoptosis.

Long Name

B Cell Lymphoma/Leukemia x Long Form

Alternate Names

BclxL

Gene Symbol

BCL2L1

Additional Bcl-xL Products

Product Documents for Bcl-xL Antibody (042) [DyLight 488]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for Bcl-xL Antibody (042) [DyLight 488]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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